Cargando…

Post-ERCP pancreatitis: Frequency and risk stratification from four tertiary care referral hospitals in South East Asia

Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a dreaded complication. But the frequency of this complication varies widely (1%–40%) among the literature and across geographical regions. With uncertainty in the estimation of occurrence and having no accepted, safe,...

Descripción completa

Detalles Bibliográficos
Autores principales: Parvin, Sultana, Islam, Md. Samiul, Majumdar, Touhidul Karim, Azam, Md. Golam, Islam, Mohammad Shohidul, Begum, Most. Rokshana, Hossain, Md. Altaf, Imam, Iftekhar, Ahmed, Faruque
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410617/
https://www.ncbi.nlm.nih.gov/pubmed/36042621
http://dx.doi.org/10.1097/MD.0000000000030271
_version_ 1784775135542116352
author Parvin, Sultana
Islam, Md. Samiul
Majumdar, Touhidul Karim
Azam, Md. Golam
Islam, Mohammad Shohidul
Begum, Most. Rokshana
Hossain, Md. Altaf
Imam, Iftekhar
Ahmed, Faruque
author_facet Parvin, Sultana
Islam, Md. Samiul
Majumdar, Touhidul Karim
Azam, Md. Golam
Islam, Mohammad Shohidul
Begum, Most. Rokshana
Hossain, Md. Altaf
Imam, Iftekhar
Ahmed, Faruque
author_sort Parvin, Sultana
collection PubMed
description Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a dreaded complication. But the frequency of this complication varies widely (1%–40%) among the literature and across geographical regions. With uncertainty in the estimation of occurrence and having no accepted, safe, effective method to prevent it, identification of its frequency and predictable risk factors is very crucial in a local or regional setting. The aim of this study was to identify the frequency of PEP and its risk factors from 4 tertiary care referral centers from a country in the South East Asia Region. This cross-sectional study was done on 1042 consecutive ERCP in adult patients (age >18 years) with baseline serum amylase levels less than 3 times the upper level of standard value. On the basis of clinical features and the amylase level at 24 hours (the next morning), the procedure was evaluated to confirm PEP. The frequency of PEP was calculated and procedure, patient, or operator-related independent risk factors for occurring PEP were analyzed using univariate and multivariate analyses. The study found 204 (19.6%) cases of PEP. In multivariate regression analysis, young age, suspected Sphincter of Oddi Dysfunction, recurrent pancreatitis, needle papillotomy, and pancreatic sphincterotomy were significant risk factors. The univariate analysis also found difficult cannulation and pancreatic duct injection with contrast as significant risk factors. Both patient-related and procedure-related risk factors acted independently for the development of PEP, which occurred in 19.6% of cases. This multicenter assessment of the frequency and risk factors for PEP in our patients would be extremely beneficial for future prevention of this complication.
format Online
Article
Text
id pubmed-9410617
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-94106172022-08-26 Post-ERCP pancreatitis: Frequency and risk stratification from four tertiary care referral hospitals in South East Asia Parvin, Sultana Islam, Md. Samiul Majumdar, Touhidul Karim Azam, Md. Golam Islam, Mohammad Shohidul Begum, Most. Rokshana Hossain, Md. Altaf Imam, Iftekhar Ahmed, Faruque Medicine (Baltimore) Research Article Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a dreaded complication. But the frequency of this complication varies widely (1%–40%) among the literature and across geographical regions. With uncertainty in the estimation of occurrence and having no accepted, safe, effective method to prevent it, identification of its frequency and predictable risk factors is very crucial in a local or regional setting. The aim of this study was to identify the frequency of PEP and its risk factors from 4 tertiary care referral centers from a country in the South East Asia Region. This cross-sectional study was done on 1042 consecutive ERCP in adult patients (age >18 years) with baseline serum amylase levels less than 3 times the upper level of standard value. On the basis of clinical features and the amylase level at 24 hours (the next morning), the procedure was evaluated to confirm PEP. The frequency of PEP was calculated and procedure, patient, or operator-related independent risk factors for occurring PEP were analyzed using univariate and multivariate analyses. The study found 204 (19.6%) cases of PEP. In multivariate regression analysis, young age, suspected Sphincter of Oddi Dysfunction, recurrent pancreatitis, needle papillotomy, and pancreatic sphincterotomy were significant risk factors. The univariate analysis also found difficult cannulation and pancreatic duct injection with contrast as significant risk factors. Both patient-related and procedure-related risk factors acted independently for the development of PEP, which occurred in 19.6% of cases. This multicenter assessment of the frequency and risk factors for PEP in our patients would be extremely beneficial for future prevention of this complication. Lippincott Williams & Wilkins 2022-08-26 /pmc/articles/PMC9410617/ /pubmed/36042621 http://dx.doi.org/10.1097/MD.0000000000030271 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle Research Article
Parvin, Sultana
Islam, Md. Samiul
Majumdar, Touhidul Karim
Azam, Md. Golam
Islam, Mohammad Shohidul
Begum, Most. Rokshana
Hossain, Md. Altaf
Imam, Iftekhar
Ahmed, Faruque
Post-ERCP pancreatitis: Frequency and risk stratification from four tertiary care referral hospitals in South East Asia
title Post-ERCP pancreatitis: Frequency and risk stratification from four tertiary care referral hospitals in South East Asia
title_full Post-ERCP pancreatitis: Frequency and risk stratification from four tertiary care referral hospitals in South East Asia
title_fullStr Post-ERCP pancreatitis: Frequency and risk stratification from four tertiary care referral hospitals in South East Asia
title_full_unstemmed Post-ERCP pancreatitis: Frequency and risk stratification from four tertiary care referral hospitals in South East Asia
title_short Post-ERCP pancreatitis: Frequency and risk stratification from four tertiary care referral hospitals in South East Asia
title_sort post-ercp pancreatitis: frequency and risk stratification from four tertiary care referral hospitals in south east asia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410617/
https://www.ncbi.nlm.nih.gov/pubmed/36042621
http://dx.doi.org/10.1097/MD.0000000000030271
work_keys_str_mv AT parvinsultana postercppancreatitisfrequencyandriskstratificationfromfourtertiarycarereferralhospitalsinsoutheastasia
AT islammdsamiul postercppancreatitisfrequencyandriskstratificationfromfourtertiarycarereferralhospitalsinsoutheastasia
AT majumdartouhidulkarim postercppancreatitisfrequencyandriskstratificationfromfourtertiarycarereferralhospitalsinsoutheastasia
AT azammdgolam postercppancreatitisfrequencyandriskstratificationfromfourtertiarycarereferralhospitalsinsoutheastasia
AT islammohammadshohidul postercppancreatitisfrequencyandriskstratificationfromfourtertiarycarereferralhospitalsinsoutheastasia
AT begummostrokshana postercppancreatitisfrequencyandriskstratificationfromfourtertiarycarereferralhospitalsinsoutheastasia
AT hossainmdaltaf postercppancreatitisfrequencyandriskstratificationfromfourtertiarycarereferralhospitalsinsoutheastasia
AT imamiftekhar postercppancreatitisfrequencyandriskstratificationfromfourtertiarycarereferralhospitalsinsoutheastasia
AT ahmedfaruque postercppancreatitisfrequencyandriskstratificationfromfourtertiarycarereferralhospitalsinsoutheastasia