Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure

Ryanodine receptors (RyRs) exhibit dynamic arrangements in cardiomyocytes, and we previously showed that ‘dispersion’ of RyR clusters disrupts Ca(2+) homeostasis during heart failure (HF) (Kolstad et al., eLife, 2018). Here, we investigated whether prolonged β-adrenergic stimulation, a hallmark of H...

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Detalles Bibliográficos
Autores principales: Shen, Xin, van den Brink, Jonas, Bergan-Dahl, Anna, Kolstad, Terje R, Norden, Einar S, Hou, Yufeng, Laasmaa, Martin, Aguilar-Sanchez, Yuriana, Quick, Ann P, Espe, Emil KS, Sjaastad, Ivar, Wehrens, Xander HT, Edwards, Andrew G, Soeller, Christian, Louch, William E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410709/
https://www.ncbi.nlm.nih.gov/pubmed/35913125
http://dx.doi.org/10.7554/eLife.77725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410709/
https://www.ncbi.nlm.nih.gov/pubmed/35913125
http://dx.doi.org/10.7554/eLife.77725

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