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Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure
Ryanodine receptors (RyRs) exhibit dynamic arrangements in cardiomyocytes, and we previously showed that ‘dispersion’ of RyR clusters disrupts Ca(2+) homeostasis during heart failure (HF) (Kolstad et al., eLife, 2018). Here, we investigated whether prolonged β-adrenergic stimulation, a hallmark of H...
Autores principales: | Shen, Xin, van den Brink, Jonas, Bergan-Dahl, Anna, Kolstad, Terje R, Norden, Einar S, Hou, Yufeng, Laasmaa, Martin, Aguilar-Sanchez, Yuriana, Quick, Ann P, Espe, Emil KS, Sjaastad, Ivar, Wehrens, Xander HT, Edwards, Andrew G, Soeller, Christian, Louch, William E |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410709/ https://www.ncbi.nlm.nih.gov/pubmed/35913125 http://dx.doi.org/10.7554/eLife.77725 |
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