Activation of LRP1 Ameliorates Cerebral Ischemia/Reperfusion Injury and Cognitive Decline by Suppressing Neuroinflammation and Oxidative Stress through TXNIP/NLRP3 Signaling Pathway in Mice

Cerebral ischemia/reperfusion (I/R) injury is a clinical event associated with high morbidity and mortality. Neuroinflammation plays a crucial role in the pathogenesis of I/R-induced brain injury and cognitive decline. Low-density lipoprotein receptor-related protein-1 (LRP1) can exert strong neurop...

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Detalles Bibliográficos
Autores principales: Yang, Cheng-Jie, Li, Xin, Feng, Xiao-Qing, Chen, Ye, Feng, Jian-Guo, Jia, Jing, Wei, Ji-Cheng, Zhou, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410841/
https://www.ncbi.nlm.nih.gov/pubmed/36035210
http://dx.doi.org/10.1155/2022/8729398

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