B-to-A transition in target DNA during retroviral integration

Integration into host target DNA (tDNA), a hallmark of retroviral replication, is mediated by the intasome, a multimer of integrase (IN) assembled on viral DNA (vDNA) ends. To ascertain aspects of tDNA recognition during integration, we have solved the 3.5 Å resolution cryo-EM structure of the mouse...

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Detalles Bibliográficos
Autores principales: Jóźwik, Ilona K, Li, Wen, Zhang, Da-Wei, Wong, Doris, Grawenhoff, Julia, Ballandras-Colas, Allison, Aiyer, Sriram, Cherepanov, Peter, Engelman, Alan N, Lyumkis, Dmitry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410886/
https://www.ncbi.nlm.nih.gov/pubmed/35947647
http://dx.doi.org/10.1093/nar/gkac644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410886/
https://www.ncbi.nlm.nih.gov/pubmed/35947647
http://dx.doi.org/10.1093/nar/gkac644

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