CGG repeats trigger translational frameshifts that generate aggregation-prone chimeric proteins

CGG repeat expansions in the FMR1 5’UTR cause the neurodegenerative disease Fragile X-associated tremor/ataxia syndrome (FXTAS). These repeats form stable RNA secondary structures that support aberrant translation in the absence of an AUG start codon (RAN translation), producing aggregate-prone pept...

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Detalles Bibliográficos
Autores principales: Wright, Shannon E, Rodriguez, Caitlin M, Monroe, Jeremy, Xing, Jiazheng, Krans, Amy, Flores, Brittany N, Barsur, Venkatesha, Ivanova, Magdalena I, Koutmou, Kristin S, Barmada, Sami J, Todd, Peter K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410890/
https://www.ncbi.nlm.nih.gov/pubmed/35904811
http://dx.doi.org/10.1093/nar/gkac626

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410890/
https://www.ncbi.nlm.nih.gov/pubmed/35904811
http://dx.doi.org/10.1093/nar/gkac626

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