Acquired Amegakaryocytic Thrombocytopenia Associated With Autoimmune Hemolytic Anemia

Acquired amegakaryocytic thrombocytopenia (AATP) is a thrombocytopenic disorder characterized by a decrease in megakaryocytes in the bone marrow. AATP is effectively treated with immunosuppressive therapy. We report a case of a 68-years-old male referred to us due to purpuric lesions on the extremit...

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Autores principales: Ikeda, Naoto, Hisano, Yuki, Kamao, Takayuki, Uno, Masatoshi, Mizushima, Takaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411021/
https://www.ncbi.nlm.nih.gov/pubmed/36042987
http://dx.doi.org/10.7759/cureus.27315
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author Ikeda, Naoto
Hisano, Yuki
Kamao, Takayuki
Uno, Masatoshi
Mizushima, Takaaki
author_facet Ikeda, Naoto
Hisano, Yuki
Kamao, Takayuki
Uno, Masatoshi
Mizushima, Takaaki
author_sort Ikeda, Naoto
collection PubMed
description Acquired amegakaryocytic thrombocytopenia (AATP) is a thrombocytopenic disorder characterized by a decrease in megakaryocytes in the bone marrow. AATP is effectively treated with immunosuppressive therapy. We report a case of a 68-years-old male referred to us due to purpuric lesions on the extremities and was noted to be thrombocytopenic. Bone marrow biopsy showed AATP with autoimmune hemolytic anemia (AIHA). Only two cases of AATP associated with AIHA have been reported. AATP should be differentiated carefully from other causes of peripheral destruction of platelets, such as immune thrombocytopenia (ITP).
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spelling pubmed-94110212022-08-29 Acquired Amegakaryocytic Thrombocytopenia Associated With Autoimmune Hemolytic Anemia Ikeda, Naoto Hisano, Yuki Kamao, Takayuki Uno, Masatoshi Mizushima, Takaaki Cureus Internal Medicine Acquired amegakaryocytic thrombocytopenia (AATP) is a thrombocytopenic disorder characterized by a decrease in megakaryocytes in the bone marrow. AATP is effectively treated with immunosuppressive therapy. We report a case of a 68-years-old male referred to us due to purpuric lesions on the extremities and was noted to be thrombocytopenic. Bone marrow biopsy showed AATP with autoimmune hemolytic anemia (AIHA). Only two cases of AATP associated with AIHA have been reported. AATP should be differentiated carefully from other causes of peripheral destruction of platelets, such as immune thrombocytopenia (ITP). Cureus 2022-07-26 /pmc/articles/PMC9411021/ /pubmed/36042987 http://dx.doi.org/10.7759/cureus.27315 Text en Copyright © 2022, Ikeda et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Ikeda, Naoto
Hisano, Yuki
Kamao, Takayuki
Uno, Masatoshi
Mizushima, Takaaki
Acquired Amegakaryocytic Thrombocytopenia Associated With Autoimmune Hemolytic Anemia
title Acquired Amegakaryocytic Thrombocytopenia Associated With Autoimmune Hemolytic Anemia
title_full Acquired Amegakaryocytic Thrombocytopenia Associated With Autoimmune Hemolytic Anemia
title_fullStr Acquired Amegakaryocytic Thrombocytopenia Associated With Autoimmune Hemolytic Anemia
title_full_unstemmed Acquired Amegakaryocytic Thrombocytopenia Associated With Autoimmune Hemolytic Anemia
title_short Acquired Amegakaryocytic Thrombocytopenia Associated With Autoimmune Hemolytic Anemia
title_sort acquired amegakaryocytic thrombocytopenia associated with autoimmune hemolytic anemia
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411021/
https://www.ncbi.nlm.nih.gov/pubmed/36042987
http://dx.doi.org/10.7759/cureus.27315
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