Ammonium tetrathiomolybdate triggers autophagy-dependent NRF2 activation in vascular endothelial cells

Ammonium tetrathiomolybdate (TTM) is a copper chelator in clinical trials for treatment of Wilson’s disease, tumors and other diseases. In the current study, we innovatively discovered that TTM is a novel NRF2 activator and illustrated that autophagy contributed to TTM-induced NRF2 activation. We sh...

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Detalles Bibliográficos
Autores principales: Zhang, Mengling, Qiu, Hongmei, Mao, Lejiao, Wang, Bin, Li, Na, Fan, Yinzhen, Weng, Ping, Hu, Siyao, Dong, Xiaomei, Qin, Xia, Chen, Chengzhi, Zou, Zhen, Yu, Chao, Zhang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411162/
https://www.ncbi.nlm.nih.gov/pubmed/36008391
http://dx.doi.org/10.1038/s41419-022-05183-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411162/
https://www.ncbi.nlm.nih.gov/pubmed/36008391
http://dx.doi.org/10.1038/s41419-022-05183-z

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