Regulation of the p38-MAPK pathway by hyperosmolarity and by WNK kinases

p38-MAPK is a stress-response kinase activated by hyperosmolarity. Here we interrogated the pathways involved. We show that p38-MAPK signaling is activated by hyperosmotic stimulation in various solutions, cell types and colonic organoids. Hyperosmolarity sensing is detected at the level of the upst...

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Detalles Bibliográficos
Autores principales: Liu, Zetao, Demian, Wael, Persaud, Avinash, Jiang, Chong, Subramanaya, Arohan R., Rotin, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411163/
https://www.ncbi.nlm.nih.gov/pubmed/36008477
http://dx.doi.org/10.1038/s41598-022-18630-w

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