Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling

Therapeutic resistance to immune checkpoint blockers (ICBs) in melanoma patients is a pressing issue, of which tumor loss of IFN-γ signaling genes is a major underlying mechanism. However, strategies of overcoming this resistance mechanism have been largely elusive. Moreover, given the indispensable...

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Detalles Bibliográficos
Autores principales: Shen, Hongxing, Huang, Fengyuan, Zhang, Xiangmin, Ojo, Oluwagbemiga A., Li, Yuebin, Trummell, Hoa Quang, Anderson, Joshua C., Fiveash, John, Bredel, Markus, Yang, Eddy S., Willey, Christopher D., Chong, Zechen, Bonner, James A., Shi, Lewis Zhichang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411168/
https://www.ncbi.nlm.nih.gov/pubmed/36008408
http://dx.doi.org/10.1038/s41467-022-32754-7

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