Automated in vivo compound screening with zebrafish and the discovery and validation of PD 81,723 as a novel angiogenesis inhibitor

Angiogenesis is a critical process in tumor progression. Inhibition of angiogenesis by blocking VEGF signaling can impair existing tumor vessels and halt tumor progression. However, the benefits are transient, and most patients who initially respond to these therapies develop resistance. Accordingly...

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Detalles Bibliográficos
Autores principales: Mauro, Antonio N., Turgeon, Paul J., Gupta, Sahil, Brand-Arzamendi, Koroboshka, Chen, Hao, Malone, Jeanie H., Ng, Robin, Ho, Kevin, Dubinsky, Michelle, Di Ciano-Oliveira, Caterina, Spring, Christopher, Plant, Pamela, Leong-Poi, Howard, Marshall, John C., Marsden, Philip A., Connelly, Kim A., Singh, Krishna K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411172/
https://www.ncbi.nlm.nih.gov/pubmed/36008455
http://dx.doi.org/10.1038/s41598-022-18230-8

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