Designed peptides as nanomolar cross-amyloid inhibitors acting via supramolecular nanofiber co-assembly

Amyloid self-assembly is linked to numerous devastating cell-degenerative diseases. However, designing inhibitors of this pathogenic process remains a major challenge. Cross-interactions between amyloid-β peptide (Aβ) and islet amyloid polypeptide (IAPP), key polypeptides of Alzheimer’s disease (AD)...

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Detalles Bibliográficos
Autores principales: Taş, Karin, Volta, Beatrice Dalla, Lindner, Christina, El Bounkari, Omar, Hille, Kathleen, Tian, Yuan, Puig-Bosch, Xènia, Ballmann, Markus, Hornung, Simon, Ortner, Martin, Prem, Sophia, Meier, Laura, Rammes, Gerhard, Haslbeck, Martin, Weber, Christian, Megens, Remco T. A., Bernhagen, Jürgen, Kapurniotu, Aphrodite
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411207/
https://www.ncbi.nlm.nih.gov/pubmed/36008417
http://dx.doi.org/10.1038/s41467-022-32688-0

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