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Activation of angiotensin-converting enzyme 2 ameliorates metabolic syndrome-induced renal damage in rats by renal TLR4 and nuclear transcription factor κB downregulation

BACKGROUND: Metabolic syndrome (MetS) is an independent risk factor for chronic kidney disease (CKD) through many mechanisms, including activation of the renin–angiotensin system. The deleterious effects of angiotensin II (Ang II) can be counterbalanced by angiotensin-converting enzyme 2 (ACE2). Dim...

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Detalles Bibliográficos
Autores principales:	El-Domiaty, Heba F., Sweed, Eman, Kora, Mona A., Zaki, Nader G., Khodir, Suzan A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411523/ https://www.ncbi.nlm.nih.gov/pubmed/36035416 http://dx.doi.org/10.3389/fmed.2022.904756

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