The microRNA-10b-Bim axis promotes cancer progression through activating autophagy in oral squamous cell carcinoma

Autophagy is related to many cellular mechanisms and dysregulation of autophagy involves the pathological process in cancer. miR-10b activates autophagy, which promotes invasion and migration of OSCC. Its functional role in the mechanism of OSCC to autophagy remains to be unclear. Overexpression of...

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Autores principales: Li, Shaoming, Gao, Ling, Liu, Jiacheng, Guo, Chao, Zheng, Jingjing, Zhi, Keqian, Ren, Wenhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411559/
https://www.ncbi.nlm.nih.gov/pubmed/36008375
http://dx.doi.org/10.1038/s41420-022-01168-1
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author Li, Shaoming
Gao, Ling
Liu, Jiacheng
Guo, Chao
Zheng, Jingjing
Zhi, Keqian
Ren, Wenhao
author_facet Li, Shaoming
Gao, Ling
Liu, Jiacheng
Guo, Chao
Zheng, Jingjing
Zhi, Keqian
Ren, Wenhao
author_sort Li, Shaoming
collection PubMed
description Autophagy is related to many cellular mechanisms and dysregulation of autophagy involves the pathological process in cancer. miR-10b activates autophagy, which promotes invasion and migration of OSCC. Its functional role in the mechanism of OSCC to autophagy remains to be unclear. Overexpression of miR-10b was followed by enhanced OSCC invasion and migration and activated autophagic protein, such as LC3II/ATG5. MiR-10b attracted Bim directly according to the Bio-informatics analyses and double luciferases reporter assays. Functional experiments further revealed that miR-10b could promote invasion and migration in vitro. In addition, miR-10b induced autophagy via inhibiting Bim in invasion and migration of OSCC. Notably, animal experiments confirmed that miR-10b-Bim promoted proliferation and autophagy in OSCC. In addition, this study provides a theoretical support for regulating the mechanism of OSCC by inducing autophagy with miR-10b-Bim as a target.
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spelling pubmed-94115592022-08-27 The microRNA-10b-Bim axis promotes cancer progression through activating autophagy in oral squamous cell carcinoma Li, Shaoming Gao, Ling Liu, Jiacheng Guo, Chao Zheng, Jingjing Zhi, Keqian Ren, Wenhao Cell Death Discov Article Autophagy is related to many cellular mechanisms and dysregulation of autophagy involves the pathological process in cancer. miR-10b activates autophagy, which promotes invasion and migration of OSCC. Its functional role in the mechanism of OSCC to autophagy remains to be unclear. Overexpression of miR-10b was followed by enhanced OSCC invasion and migration and activated autophagic protein, such as LC3II/ATG5. MiR-10b attracted Bim directly according to the Bio-informatics analyses and double luciferases reporter assays. Functional experiments further revealed that miR-10b could promote invasion and migration in vitro. In addition, miR-10b induced autophagy via inhibiting Bim in invasion and migration of OSCC. Notably, animal experiments confirmed that miR-10b-Bim promoted proliferation and autophagy in OSCC. In addition, this study provides a theoretical support for regulating the mechanism of OSCC by inducing autophagy with miR-10b-Bim as a target. Nature Publishing Group UK 2022-08-25 /pmc/articles/PMC9411559/ /pubmed/36008375 http://dx.doi.org/10.1038/s41420-022-01168-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Li, Shaoming
Gao, Ling
Liu, Jiacheng
Guo, Chao
Zheng, Jingjing
Zhi, Keqian
Ren, Wenhao
The microRNA-10b-Bim axis promotes cancer progression through activating autophagy in oral squamous cell carcinoma
title The microRNA-10b-Bim axis promotes cancer progression through activating autophagy in oral squamous cell carcinoma
title_full The microRNA-10b-Bim axis promotes cancer progression through activating autophagy in oral squamous cell carcinoma
title_fullStr The microRNA-10b-Bim axis promotes cancer progression through activating autophagy in oral squamous cell carcinoma
title_full_unstemmed The microRNA-10b-Bim axis promotes cancer progression through activating autophagy in oral squamous cell carcinoma
title_short The microRNA-10b-Bim axis promotes cancer progression through activating autophagy in oral squamous cell carcinoma
title_sort microrna-10b-bim axis promotes cancer progression through activating autophagy in oral squamous cell carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411559/
https://www.ncbi.nlm.nih.gov/pubmed/36008375
http://dx.doi.org/10.1038/s41420-022-01168-1
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