Cargando…

Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein

Alpha-synuclein (αSyn) is a protein involved in neurodegenerative disorders including Parkinson’s disease. Amyloid formation of αSyn can be modulated by the ‘P1 region’ (residues 36-42). Here, mutational studies of P1 reveal that Y39A and S42A extend the lag-phase of αSyn amyloid formation in vitro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ulamec, Sabine M., Maya-Martinez, Roberto, Byrd, Emily J., Dewison, Katherine M., Xu, Yong, Willis, Leon F., Sobott, Frank, Heath, George R., van Oosten Hawle, Patricija, Buchman, Vladimir L., Radford, Sheena E., Brockwell, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411612/ https://www.ncbi.nlm.nih.gov/pubmed/36008493 http://dx.doi.org/10.1038/s41467-022-32687-1

Ejemplares similares

A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function
por: Doherty, Ciaran P. A., et al.
Publicado: (2020)

Global Proteotoxicity Caused by Human β(2) Microglobulin Variants Impairs the Unfolded Protein Response in C. elegans
por: Good, Sarah C., et al.
Publicado: (2021)

Taking Charge: Metal Ions Accelerate Amyloid Aggregation in Sequence Variants of α-Synuclein
por: Byrd, Emily J., et al.
Publicado: (2023)

Organismal Roles of Hsp90
por: van Oosten-Hawle, Patricija
Publicado: (2023)

Exploiting inter-tissue stress signaling mechanisms to preserve organismal proteostasis during aging
por: van Oosten-Hawle, Patricija
Publicado: (2023)

Looking Beyond the Core: The Role of Flanking Regions in the Aggregation of Amyloidogenic Peptides and Proteins
por: Ulamec, Sabine M., et al.
Publicado: (2020)

Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling
por: van Oosten-Hawle, Patricija, et al.
Publicado: (2014)

Regulation of cell-non-autonomous proteostasis in metazoans
por: O'Brien, Daniel, et al.
Publicado: (2016)

The Intestine as a Lifespan- and Proteostasis-Promoting Signaling Tissue
por: Hodge, Francesca, et al.
Publicado: (2022)

Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly
por: Xu, Yong, et al.
Publicado: (2022)

Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-β deposition in a mouse model of Alzheimer’s disease
por: Lackie, Rachel E., et al.
Publicado: (2020)

Transcellular chaperone signaling is an intercellular stress-response distinct from the HSF-1–mediated heat shock response
por: Miles, Jay, et al.
Publicado: (2023)

The N-terminal Helix Is a Post-assembly Clamp in the Bacterial Outer Membrane Protein PagP
por: Huysmans, Gerard H.M., et al.
Publicado: (2007)

Duplication of hsp-110 Is Implicated in Differential Success of Globodera Species under Climate Change
por: Jones, Laura M, et al.
Publicado: (2018)

Intermediates: ubiquitous species on folding energy landscapes?
por: Brockwell, David J, et al.
Publicado: (2007)

How important is the N-terminal acetylation of alpha-synuclein for its function and aggregation into amyloids?
por: Iyer, Aditya, et al.
Publicado: (2022)

Role of C-terminal negative charges and tyrosine residues in fibril formation of α-synuclein
por: Izawa, Yasutaka, et al.
Publicado: (2012)

Force-induced remodelling of proteins and their complexes
por: Chen, Yun, et al.
Publicado: (2015)

Outer membrane protein folding from an energy landscape perspective
por: Schiffrin, Bob, et al.
Publicado: (2017)

C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH
por: van der Wateren, Ingrid M., et al.
Publicado: (2018)

Amyloid plaques beyond Aβ: a survey of the diverse modulators of amyloid aggregation
por: Stewart, Katie L., et al.
Publicado: (2017)

A PQM-1-Mediated Response Triggers Transcellular Chaperone Signaling and Regulates Organismal Proteostasis
por: O’Brien, Daniel, et al.
Publicado: (2018)

Role of the lipid bilayer in outer membrane protein folding in Gram-negative bacteria
por: Horne, Jim E., et al.
Publicado: (2020)

The N-Terminal Residues 43 to 60 Form the Interface for Dopamine Mediated α-Synuclein Dimerisation
por: Leong, Su Ling, et al.
Publicado: (2015)

The differential solvent exposure of N-terminal residues provides “fingerprints” of alpha-synuclein fibrillar polymorphs
por: Landureau, Maud, et al.
Publicado: (2021)

Modulation of α-synuclein expression in transgenic animals for modelling synucleinopathies — is the juice worth the squeeze?
por: Buchman, Vladimir L., et al.
Publicado: (2008)

The uniqueness of flow in probing the aggregation behavior of clinically relevant antibodies
por: Willis, Leon F., et al.
Publicado: (2020)

Mechanistic studies of the biogenesis and folding of outer membrane proteins in vitro and in vivo: What have we learned to date?
por: McMorran, Lindsay M., et al.
Publicado: (2014)

Using protein engineering to understand and modulate aggregation
por: Ebo, Jessica S, et al.
Publicado: (2020)

Using extensional flow to reveal diverse aggregation landscapes for three IgG1 molecules
por: Willis, Leon F., et al.
Publicado: (2018)

Understanding the complex mechanisms of β(2)-microglobulin amyloid assembly
por: Eichner, Timo, et al.
Publicado: (2011)

γ-synuclein is a novel player in the control of body lipid metabolism
por: Millership, Steven, et al.
Publicado: (2013)

PyXlinkViewer: A flexible tool for visualization of protein chemical crosslinking data within the PyMOL molecular graphics system
por: Schiffrin, Bob, et al.
Publicado: (2020)

α-Synuclein-derived lipoparticles in the study of α-Synuclein amyloid fibril formation
por: Falke, Marcel, et al.
Publicado: (2019)

Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins
por: Carnazza, Kathryn E., et al.
Publicado: (2022)

Metal ions shape α-synuclein
por: Moons, Rani, et al.
Publicado: (2020)

Alpha-Synuclein Amyloid Aggregation Is Inhibited by Sulfated Aromatic Polymers and Pyridinium Polycation
por: Semenyuk, Pavel, et al.
Publicado: (2020)

Triple-Knockout, Synuclein-Free Mice Display Compromised Lipid Pattern
por: Guschina, Irina A., et al.
Publicado: (2021)

Assessing the causes and consequences of co-polymerization in amyloid formation
por: Sarell, Claire J, et al.
Publicado: (2013)

Inhibition of α-Synuclein Fibrillization by Dopamine Is Mediated by Interactions with Five C-Terminal Residues and with E83 in the NAC Region
por: Herrera, Fernando E., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_ntu9tsca41o89bql90nf7rpqfe