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Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein

Alpha-synuclein (αSyn) is a protein involved in neurodegenerative disorders including Parkinson’s disease. Amyloid formation of αSyn can be modulated by the ‘P1 region’ (residues 36-42). Here, mutational studies of P1 reveal that Y39A and S42A extend the lag-phase of αSyn amyloid formation in vitro...

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Detalles Bibliográficos
Autores principales:	Ulamec, Sabine M., Maya-Martinez, Roberto, Byrd, Emily J., Dewison, Katherine M., Xu, Yong, Willis, Leon F., Sobott, Frank, Heath, George R., van Oosten Hawle, Patricija, Buchman, Vladimir L., Radford, Sheena E., Brockwell, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411612/ https://www.ncbi.nlm.nih.gov/pubmed/36008493 http://dx.doi.org/10.1038/s41467-022-32687-1

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