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Variable effects of omaveloxolone (RTA408) on primary fibroblasts with mitochondrial defects

Omaveloxolone (RTA408) is a second-generation oleanane triterpenoid Nrf2 inducer with antioxidant and anti-inflammatory properties and was reported to improve mitochondrial bioenergetics. It is currently being tested in medical trials for Friedrich ataxia, a genetic, multi-organ disease involving mi...

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Detalles Bibliográficos
Autores principales:	Zighan, Madleen, Arkadir, David, Douiev, Liza, Keller, Guy, Miller, Chaya, Saada, Ann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411646/ https://www.ncbi.nlm.nih.gov/pubmed/36032663 http://dx.doi.org/10.3389/fmolb.2022.890653

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