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Lung and gut microbiomes in pulmonary aspergillosis: Exploring adjunctive therapies to combat the disease
Species within the Aspergillus spp. cause a wide range of infections in humans, including invasive pulmonary aspergillosis, chronic pulmonary aspergillosis, and allergic bronchopulmonary aspergillosis, and are associated with high mortality rates. The incidence of pulmonary aspergillosis (PA) is on...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411651/ https://www.ncbi.nlm.nih.gov/pubmed/36032147 http://dx.doi.org/10.3389/fimmu.2022.988708 |
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author | Cai, Liuyang Gao, Peigen Wang, Zeyu Dai, Chenyang Ning, Ye Ilkit, Macit Xue, Xiaochun Xiao, Jinzhou Chen, Chang |
author_facet | Cai, Liuyang Gao, Peigen Wang, Zeyu Dai, Chenyang Ning, Ye Ilkit, Macit Xue, Xiaochun Xiao, Jinzhou Chen, Chang |
author_sort | Cai, Liuyang |
collection | PubMed |
description | Species within the Aspergillus spp. cause a wide range of infections in humans, including invasive pulmonary aspergillosis, chronic pulmonary aspergillosis, and allergic bronchopulmonary aspergillosis, and are associated with high mortality rates. The incidence of pulmonary aspergillosis (PA) is on the rise, and the emergence of triazole-resistant Aspergillus spp. isolates, especially Aspergillus fumigatus, limits the efficacy of mold-active triazoles. Therefore, host-directed and novel adjunctive therapies are required to more effectively combat PA. In this review, we focus on PA from a microbiome perspective. We provide a general overview of the effects of the lung and gut microbiomes on the growth of Aspergillus spp. and host immunity. We highlight the potential of the microbiome as a therapeutic target for PA. |
format | Online Article Text |
id | pubmed-9411651 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94116512022-08-27 Lung and gut microbiomes in pulmonary aspergillosis: Exploring adjunctive therapies to combat the disease Cai, Liuyang Gao, Peigen Wang, Zeyu Dai, Chenyang Ning, Ye Ilkit, Macit Xue, Xiaochun Xiao, Jinzhou Chen, Chang Front Immunol Immunology Species within the Aspergillus spp. cause a wide range of infections in humans, including invasive pulmonary aspergillosis, chronic pulmonary aspergillosis, and allergic bronchopulmonary aspergillosis, and are associated with high mortality rates. The incidence of pulmonary aspergillosis (PA) is on the rise, and the emergence of triazole-resistant Aspergillus spp. isolates, especially Aspergillus fumigatus, limits the efficacy of mold-active triazoles. Therefore, host-directed and novel adjunctive therapies are required to more effectively combat PA. In this review, we focus on PA from a microbiome perspective. We provide a general overview of the effects of the lung and gut microbiomes on the growth of Aspergillus spp. and host immunity. We highlight the potential of the microbiome as a therapeutic target for PA. Frontiers Media S.A. 2022-08-12 /pmc/articles/PMC9411651/ /pubmed/36032147 http://dx.doi.org/10.3389/fimmu.2022.988708 Text en Copyright © 2022 Cai, Gao, Wang, Dai, Ning, Ilkit, Xue, Xiao and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Cai, Liuyang Gao, Peigen Wang, Zeyu Dai, Chenyang Ning, Ye Ilkit, Macit Xue, Xiaochun Xiao, Jinzhou Chen, Chang Lung and gut microbiomes in pulmonary aspergillosis: Exploring adjunctive therapies to combat the disease |
title | Lung and gut microbiomes in pulmonary aspergillosis: Exploring adjunctive therapies to combat the disease |
title_full | Lung and gut microbiomes in pulmonary aspergillosis: Exploring adjunctive therapies to combat the disease |
title_fullStr | Lung and gut microbiomes in pulmonary aspergillosis: Exploring adjunctive therapies to combat the disease |
title_full_unstemmed | Lung and gut microbiomes in pulmonary aspergillosis: Exploring adjunctive therapies to combat the disease |
title_short | Lung and gut microbiomes in pulmonary aspergillosis: Exploring adjunctive therapies to combat the disease |
title_sort | lung and gut microbiomes in pulmonary aspergillosis: exploring adjunctive therapies to combat the disease |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411651/ https://www.ncbi.nlm.nih.gov/pubmed/36032147 http://dx.doi.org/10.3389/fimmu.2022.988708 |
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