Cargando…

Lung and gut microbiomes in pulmonary aspergillosis: Exploring adjunctive therapies to combat the disease

Species within the Aspergillus spp. cause a wide range of infections in humans, including invasive pulmonary aspergillosis, chronic pulmonary aspergillosis, and allergic bronchopulmonary aspergillosis, and are associated with high mortality rates. The incidence of pulmonary aspergillosis (PA) is on...

Descripción completa

Detalles Bibliográficos
Autores principales: Cai, Liuyang, Gao, Peigen, Wang, Zeyu, Dai, Chenyang, Ning, Ye, Ilkit, Macit, Xue, Xiaochun, Xiao, Jinzhou, Chen, Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411651/
https://www.ncbi.nlm.nih.gov/pubmed/36032147
http://dx.doi.org/10.3389/fimmu.2022.988708
_version_ 1784775316360658944
author Cai, Liuyang
Gao, Peigen
Wang, Zeyu
Dai, Chenyang
Ning, Ye
Ilkit, Macit
Xue, Xiaochun
Xiao, Jinzhou
Chen, Chang
author_facet Cai, Liuyang
Gao, Peigen
Wang, Zeyu
Dai, Chenyang
Ning, Ye
Ilkit, Macit
Xue, Xiaochun
Xiao, Jinzhou
Chen, Chang
author_sort Cai, Liuyang
collection PubMed
description Species within the Aspergillus spp. cause a wide range of infections in humans, including invasive pulmonary aspergillosis, chronic pulmonary aspergillosis, and allergic bronchopulmonary aspergillosis, and are associated with high mortality rates. The incidence of pulmonary aspergillosis (PA) is on the rise, and the emergence of triazole-resistant Aspergillus spp. isolates, especially Aspergillus fumigatus, limits the efficacy of mold-active triazoles. Therefore, host-directed and novel adjunctive therapies are required to more effectively combat PA. In this review, we focus on PA from a microbiome perspective. We provide a general overview of the effects of the lung and gut microbiomes on the growth of Aspergillus spp. and host immunity. We highlight the potential of the microbiome as a therapeutic target for PA.
format Online
Article
Text
id pubmed-9411651
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-94116512022-08-27 Lung and gut microbiomes in pulmonary aspergillosis: Exploring adjunctive therapies to combat the disease Cai, Liuyang Gao, Peigen Wang, Zeyu Dai, Chenyang Ning, Ye Ilkit, Macit Xue, Xiaochun Xiao, Jinzhou Chen, Chang Front Immunol Immunology Species within the Aspergillus spp. cause a wide range of infections in humans, including invasive pulmonary aspergillosis, chronic pulmonary aspergillosis, and allergic bronchopulmonary aspergillosis, and are associated with high mortality rates. The incidence of pulmonary aspergillosis (PA) is on the rise, and the emergence of triazole-resistant Aspergillus spp. isolates, especially Aspergillus fumigatus, limits the efficacy of mold-active triazoles. Therefore, host-directed and novel adjunctive therapies are required to more effectively combat PA. In this review, we focus on PA from a microbiome perspective. We provide a general overview of the effects of the lung and gut microbiomes on the growth of Aspergillus spp. and host immunity. We highlight the potential of the microbiome as a therapeutic target for PA. Frontiers Media S.A. 2022-08-12 /pmc/articles/PMC9411651/ /pubmed/36032147 http://dx.doi.org/10.3389/fimmu.2022.988708 Text en Copyright © 2022 Cai, Gao, Wang, Dai, Ning, Ilkit, Xue, Xiao and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Cai, Liuyang
Gao, Peigen
Wang, Zeyu
Dai, Chenyang
Ning, Ye
Ilkit, Macit
Xue, Xiaochun
Xiao, Jinzhou
Chen, Chang
Lung and gut microbiomes in pulmonary aspergillosis: Exploring adjunctive therapies to combat the disease
title Lung and gut microbiomes in pulmonary aspergillosis: Exploring adjunctive therapies to combat the disease
title_full Lung and gut microbiomes in pulmonary aspergillosis: Exploring adjunctive therapies to combat the disease
title_fullStr Lung and gut microbiomes in pulmonary aspergillosis: Exploring adjunctive therapies to combat the disease
title_full_unstemmed Lung and gut microbiomes in pulmonary aspergillosis: Exploring adjunctive therapies to combat the disease
title_short Lung and gut microbiomes in pulmonary aspergillosis: Exploring adjunctive therapies to combat the disease
title_sort lung and gut microbiomes in pulmonary aspergillosis: exploring adjunctive therapies to combat the disease
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411651/
https://www.ncbi.nlm.nih.gov/pubmed/36032147
http://dx.doi.org/10.3389/fimmu.2022.988708
work_keys_str_mv AT cailiuyang lungandgutmicrobiomesinpulmonaryaspergillosisexploringadjunctivetherapiestocombatthedisease
AT gaopeigen lungandgutmicrobiomesinpulmonaryaspergillosisexploringadjunctivetherapiestocombatthedisease
AT wangzeyu lungandgutmicrobiomesinpulmonaryaspergillosisexploringadjunctivetherapiestocombatthedisease
AT daichenyang lungandgutmicrobiomesinpulmonaryaspergillosisexploringadjunctivetherapiestocombatthedisease
AT ningye lungandgutmicrobiomesinpulmonaryaspergillosisexploringadjunctivetherapiestocombatthedisease
AT ilkitmacit lungandgutmicrobiomesinpulmonaryaspergillosisexploringadjunctivetherapiestocombatthedisease
AT xuexiaochun lungandgutmicrobiomesinpulmonaryaspergillosisexploringadjunctivetherapiestocombatthedisease
AT xiaojinzhou lungandgutmicrobiomesinpulmonaryaspergillosisexploringadjunctivetherapiestocombatthedisease
AT chenchang lungandgutmicrobiomesinpulmonaryaspergillosisexploringadjunctivetherapiestocombatthedisease