Protein-Ligand Identification and In Vitro Inhibitory Effects of Cathine on 11 Major Human Drug Metabolizing Cytochrome P450s

Cathine is the stable form of cathinone, the major active compound found in khat (Catha edulis Forsk) plant. Khat was found to inhibit major phase I drug metabolizing cytochrome P450 (CYP) enzyme activities in vitro and in vivo. With the upsurge of khat consumption and the potential use of cathine t...

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Detalles Bibliográficos
Autores principales: Lim, Sharoen Y. M., Loo, Jason Siau Ee, Alshagga, Mustafa, Alshawsh, Mohammed A., Ong, Chin E., Pan, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411691/
https://www.ncbi.nlm.nih.gov/pubmed/35658727
http://dx.doi.org/10.1177/10915818221103790

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