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Contribution of muscle satellite cells to sarcopenia
Sarcopenia, a disorder characterized by age-related muscle loss and reduced muscle strength, is associated with decreased individual independence and quality of life, as well as a high risk of death. Skeletal muscle houses a normally mitotically quiescent population of adult stem cells called muscle...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411786/ https://www.ncbi.nlm.nih.gov/pubmed/36035464 http://dx.doi.org/10.3389/fphys.2022.892749 |
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author | Huo, Fengjiao Liu, Qing Liu, Hailiang |
author_facet | Huo, Fengjiao Liu, Qing Liu, Hailiang |
author_sort | Huo, Fengjiao |
collection | PubMed |
description | Sarcopenia, a disorder characterized by age-related muscle loss and reduced muscle strength, is associated with decreased individual independence and quality of life, as well as a high risk of death. Skeletal muscle houses a normally mitotically quiescent population of adult stem cells called muscle satellite cells (MuSCs) that are responsible for muscle maintenance, growth, repair, and regeneration throughout the life cycle. Patients with sarcopenia are often exhibit dysregulation of MuSCs homeostasis. In this review, we focus on the etiology, assessment, and treatment of sarcopenia. We also discuss phenotypic and regulatory mechanisms of MuSC quiescence, activation, and aging states, as well as the controversy between MuSC depletion and sarcopenia. Finally, we give a multi-dimensional treatment strategy for sarcopenia based on improving MuSC function. |
format | Online Article Text |
id | pubmed-9411786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94117862022-08-27 Contribution of muscle satellite cells to sarcopenia Huo, Fengjiao Liu, Qing Liu, Hailiang Front Physiol Physiology Sarcopenia, a disorder characterized by age-related muscle loss and reduced muscle strength, is associated with decreased individual independence and quality of life, as well as a high risk of death. Skeletal muscle houses a normally mitotically quiescent population of adult stem cells called muscle satellite cells (MuSCs) that are responsible for muscle maintenance, growth, repair, and regeneration throughout the life cycle. Patients with sarcopenia are often exhibit dysregulation of MuSCs homeostasis. In this review, we focus on the etiology, assessment, and treatment of sarcopenia. We also discuss phenotypic and regulatory mechanisms of MuSC quiescence, activation, and aging states, as well as the controversy between MuSC depletion and sarcopenia. Finally, we give a multi-dimensional treatment strategy for sarcopenia based on improving MuSC function. Frontiers Media S.A. 2022-08-12 /pmc/articles/PMC9411786/ /pubmed/36035464 http://dx.doi.org/10.3389/fphys.2022.892749 Text en Copyright © 2022 Huo, Liu and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Huo, Fengjiao Liu, Qing Liu, Hailiang Contribution of muscle satellite cells to sarcopenia |
title | Contribution of muscle satellite cells to sarcopenia |
title_full | Contribution of muscle satellite cells to sarcopenia |
title_fullStr | Contribution of muscle satellite cells to sarcopenia |
title_full_unstemmed | Contribution of muscle satellite cells to sarcopenia |
title_short | Contribution of muscle satellite cells to sarcopenia |
title_sort | contribution of muscle satellite cells to sarcopenia |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411786/ https://www.ncbi.nlm.nih.gov/pubmed/36035464 http://dx.doi.org/10.3389/fphys.2022.892749 |
work_keys_str_mv | AT huofengjiao contributionofmusclesatellitecellstosarcopenia AT liuqing contributionofmusclesatellitecellstosarcopenia AT liuhailiang contributionofmusclesatellitecellstosarcopenia |