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Development and external validation of a dynamic nomogram to predict the survival for adenosquamous carcinoma of the pancreas

OBJECTIVE: We aimed to develop a nomogram to predict the survival and prognosis of adenosquamous carcinoma of the pancreas (ASCP). BACKGROUND: Adenosquamous carcinoma of the pancreas (ASCP) is a relatively rare histological subtype of pancreatic exocrine neoplasms. It was reported a worse survival i...

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Autores principales: Ren, Chao, Ma, Yifei, Jin, Jiabin, Ding, Jiachun, Jiang, Yina, Wu, Yinying, Li, Wei, Yang, Xue, Han, Liang, Ma, Qingyong, Wu, Zheng, Shi, Yusheng, Wang, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411813/
https://www.ncbi.nlm.nih.gov/pubmed/36033500
http://dx.doi.org/10.3389/fonc.2022.927107
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author Ren, Chao
Ma, Yifei
Jin, Jiabin
Ding, Jiachun
Jiang, Yina
Wu, Yinying
Li, Wei
Yang, Xue
Han, Liang
Ma, Qingyong
Wu, Zheng
Shi, Yusheng
Wang, Zheng
author_facet Ren, Chao
Ma, Yifei
Jin, Jiabin
Ding, Jiachun
Jiang, Yina
Wu, Yinying
Li, Wei
Yang, Xue
Han, Liang
Ma, Qingyong
Wu, Zheng
Shi, Yusheng
Wang, Zheng
author_sort Ren, Chao
collection PubMed
description OBJECTIVE: We aimed to develop a nomogram to predict the survival and prognosis of adenosquamous carcinoma of the pancreas (ASCP). BACKGROUND: Adenosquamous carcinoma of the pancreas (ASCP) is a relatively rare histological subtype of pancreatic exocrine neoplasms. It was reported a worse survival in ASCP than in pancreatic adenocarcinoma (PDAC). Prediction of ASCP prognosis is of great importance. METHODS: Histologically confirmed ASCP patients from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) Program database were finally enrolled and divided into development and internal validation cohorts. Moreover, a multi-center cohort of 70 patients from China was registered as the external validation. A nomogram was developed based on independent predictors of ASCP determined in multivariable analysis. RESULTS: A total of 233 patients from SEER were finally included. Univariate and Multivariate analysis showed that tumor size, radiotherapy, chemotherapy, and lymph node ratio (LNR) were considered the independent prognostic indicators. We developed a nomogram according to these four parameters. The C index of the nomogram in the development cohort was 0.696. Through analysis of the area under the curve (AUC) of the different cohorts, we observed that the predictive efficacy of the nomogram for 1-, and 2-year overall survival (OS) were better than those of the American Joint Committee on Cancer (AJCC) TNM (8(th)) staging system both in the development and validation cohort. External validation confirmed that 1-year survival is 67.2% vs. 29.7%, similar to the internal cohort analysis. CONCLUSION: The nomogram showed good performance in predicting the survival of ASCP. It could help surgeons to make clinical decisions and develop further plans.
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spelling pubmed-94118132022-08-27 Development and external validation of a dynamic nomogram to predict the survival for adenosquamous carcinoma of the pancreas Ren, Chao Ma, Yifei Jin, Jiabin Ding, Jiachun Jiang, Yina Wu, Yinying Li, Wei Yang, Xue Han, Liang Ma, Qingyong Wu, Zheng Shi, Yusheng Wang, Zheng Front Oncol Oncology OBJECTIVE: We aimed to develop a nomogram to predict the survival and prognosis of adenosquamous carcinoma of the pancreas (ASCP). BACKGROUND: Adenosquamous carcinoma of the pancreas (ASCP) is a relatively rare histological subtype of pancreatic exocrine neoplasms. It was reported a worse survival in ASCP than in pancreatic adenocarcinoma (PDAC). Prediction of ASCP prognosis is of great importance. METHODS: Histologically confirmed ASCP patients from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) Program database were finally enrolled and divided into development and internal validation cohorts. Moreover, a multi-center cohort of 70 patients from China was registered as the external validation. A nomogram was developed based on independent predictors of ASCP determined in multivariable analysis. RESULTS: A total of 233 patients from SEER were finally included. Univariate and Multivariate analysis showed that tumor size, radiotherapy, chemotherapy, and lymph node ratio (LNR) were considered the independent prognostic indicators. We developed a nomogram according to these four parameters. The C index of the nomogram in the development cohort was 0.696. Through analysis of the area under the curve (AUC) of the different cohorts, we observed that the predictive efficacy of the nomogram for 1-, and 2-year overall survival (OS) were better than those of the American Joint Committee on Cancer (AJCC) TNM (8(th)) staging system both in the development and validation cohort. External validation confirmed that 1-year survival is 67.2% vs. 29.7%, similar to the internal cohort analysis. CONCLUSION: The nomogram showed good performance in predicting the survival of ASCP. It could help surgeons to make clinical decisions and develop further plans. Frontiers Media S.A. 2022-08-12 /pmc/articles/PMC9411813/ /pubmed/36033500 http://dx.doi.org/10.3389/fonc.2022.927107 Text en Copyright © 2022 Ren, Ma, Jin, Ding, Jiang, Wu, Li, Yang, Han, Ma, Wu, Shi and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ren, Chao
Ma, Yifei
Jin, Jiabin
Ding, Jiachun
Jiang, Yina
Wu, Yinying
Li, Wei
Yang, Xue
Han, Liang
Ma, Qingyong
Wu, Zheng
Shi, Yusheng
Wang, Zheng
Development and external validation of a dynamic nomogram to predict the survival for adenosquamous carcinoma of the pancreas
title Development and external validation of a dynamic nomogram to predict the survival for adenosquamous carcinoma of the pancreas
title_full Development and external validation of a dynamic nomogram to predict the survival for adenosquamous carcinoma of the pancreas
title_fullStr Development and external validation of a dynamic nomogram to predict the survival for adenosquamous carcinoma of the pancreas
title_full_unstemmed Development and external validation of a dynamic nomogram to predict the survival for adenosquamous carcinoma of the pancreas
title_short Development and external validation of a dynamic nomogram to predict the survival for adenosquamous carcinoma of the pancreas
title_sort development and external validation of a dynamic nomogram to predict the survival for adenosquamous carcinoma of the pancreas
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411813/
https://www.ncbi.nlm.nih.gov/pubmed/36033500
http://dx.doi.org/10.3389/fonc.2022.927107
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