Cargando…

Gestational age and risk of intellectual disability: a population-based cohort study

OBJECTIVE: To examine the association between gestational age at birth and risk of clinically diagnosed intellectual disability (ID) week by week to provide a detailed description of ID risk across the entire range of gestational ages and by severity of ID. METHODS: All individuals born alive in Swe...

Descripción completa

Detalles Bibliográficos
Autores principales: Yin, Weiyao, Döring, Nora, Persson, Monica S M, Persson, Martina, Tedroff, Kristina, Ådén, Ulrika, Sandin, Sven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411878/
https://www.ncbi.nlm.nih.gov/pubmed/35470219
http://dx.doi.org/10.1136/archdischild-2021-323308
_version_ 1784775364178870272
author Yin, Weiyao
Döring, Nora
Persson, Monica S M
Persson, Martina
Tedroff, Kristina
Ådén, Ulrika
Sandin, Sven
author_facet Yin, Weiyao
Döring, Nora
Persson, Monica S M
Persson, Martina
Tedroff, Kristina
Ådén, Ulrika
Sandin, Sven
author_sort Yin, Weiyao
collection PubMed
description OBJECTIVE: To examine the association between gestational age at birth and risk of clinically diagnosed intellectual disability (ID) week by week to provide a detailed description of ID risk across the entire range of gestational ages and by severity of ID. METHODS: All individuals born alive in Sweden 1974–2017 were prospectively followed up from birth until 2017 using national registers. The HRs for ID according to weekly gestational age and gestational age categories were determined using Cox models. Sibling analyses were conducted to adjust for familial confounding. RESULTS: The study included 3 572 845 live births. During the follow-up, 26 596 ID cases were registered. The adjusted weekly estimates showed a gradual increase in risk of ID from week 40 to week 24 (adjusted HR(37weeks)=1.80 (1.74 to 1.87), aHR(32weeks)=3.93 (3.73 to 4.13), aHR(28weeks)=7.53 (6.95 to 8.16), aHR(24weeks)=21.58 (18.62 to 25.00)) and from week 41 onwards (aHR(42weeks)=1.26 (1.19 to 1.32)), with statistically significantly higher risks across the range of gestational age compared with infants born at week 40. The associations were consistent in mild, moderate and severe/profound ID but most prominent for severe/profound ID. CONCLUSION: The risk of ID increased weekly as the date of delivery moved away from 40 weeks, both preterm and post-term. The results remained robust after detailed adjustment for confounding, including familial confounding.
format Online
Article
Text
id pubmed-9411878
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-94118782022-09-12 Gestational age and risk of intellectual disability: a population-based cohort study Yin, Weiyao Döring, Nora Persson, Monica S M Persson, Martina Tedroff, Kristina Ådén, Ulrika Sandin, Sven Arch Dis Child Original Research OBJECTIVE: To examine the association between gestational age at birth and risk of clinically diagnosed intellectual disability (ID) week by week to provide a detailed description of ID risk across the entire range of gestational ages and by severity of ID. METHODS: All individuals born alive in Sweden 1974–2017 were prospectively followed up from birth until 2017 using national registers. The HRs for ID according to weekly gestational age and gestational age categories were determined using Cox models. Sibling analyses were conducted to adjust for familial confounding. RESULTS: The study included 3 572 845 live births. During the follow-up, 26 596 ID cases were registered. The adjusted weekly estimates showed a gradual increase in risk of ID from week 40 to week 24 (adjusted HR(37weeks)=1.80 (1.74 to 1.87), aHR(32weeks)=3.93 (3.73 to 4.13), aHR(28weeks)=7.53 (6.95 to 8.16), aHR(24weeks)=21.58 (18.62 to 25.00)) and from week 41 onwards (aHR(42weeks)=1.26 (1.19 to 1.32)), with statistically significantly higher risks across the range of gestational age compared with infants born at week 40. The associations were consistent in mild, moderate and severe/profound ID but most prominent for severe/profound ID. CONCLUSION: The risk of ID increased weekly as the date of delivery moved away from 40 weeks, both preterm and post-term. The results remained robust after detailed adjustment for confounding, including familial confounding. BMJ Publishing Group 2022-09 2022-04-25 /pmc/articles/PMC9411878/ /pubmed/35470219 http://dx.doi.org/10.1136/archdischild-2021-323308 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Original Research
Yin, Weiyao
Döring, Nora
Persson, Monica S M
Persson, Martina
Tedroff, Kristina
Ådén, Ulrika
Sandin, Sven
Gestational age and risk of intellectual disability: a population-based cohort study
title Gestational age and risk of intellectual disability: a population-based cohort study
title_full Gestational age and risk of intellectual disability: a population-based cohort study
title_fullStr Gestational age and risk of intellectual disability: a population-based cohort study
title_full_unstemmed Gestational age and risk of intellectual disability: a population-based cohort study
title_short Gestational age and risk of intellectual disability: a population-based cohort study
title_sort gestational age and risk of intellectual disability: a population-based cohort study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411878/
https://www.ncbi.nlm.nih.gov/pubmed/35470219
http://dx.doi.org/10.1136/archdischild-2021-323308
work_keys_str_mv AT yinweiyao gestationalageandriskofintellectualdisabilityapopulationbasedcohortstudy
AT doringnora gestationalageandriskofintellectualdisabilityapopulationbasedcohortstudy
AT perssonmonicasm gestationalageandriskofintellectualdisabilityapopulationbasedcohortstudy
AT perssonmartina gestationalageandriskofintellectualdisabilityapopulationbasedcohortstudy
AT tedroffkristina gestationalageandriskofintellectualdisabilityapopulationbasedcohortstudy
AT adenulrika gestationalageandriskofintellectualdisabilityapopulationbasedcohortstudy
AT sandinsven gestationalageandriskofintellectualdisabilityapopulationbasedcohortstudy