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Suppression of host nocifensive behavior by parasitoid wasp venom

The parasitoid wasp Ampulex compressa envenomates the brain of its host the American cockroach (Periplaneta americana), thereby making it a behaviorally compliant food supply for its offspring. The target of venom injection is a locomotory command center in the brain called the central complex. In t...

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Autores principales: Rana, Amit, Emanuel, Stav, Adams, Michael E., Libersat, Frederic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411936/
https://www.ncbi.nlm.nih.gov/pubmed/36035493
http://dx.doi.org/10.3389/fphys.2022.907041
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author Rana, Amit
Emanuel, Stav
Adams, Michael E.
Libersat, Frederic
author_facet Rana, Amit
Emanuel, Stav
Adams, Michael E.
Libersat, Frederic
author_sort Rana, Amit
collection PubMed
description The parasitoid wasp Ampulex compressa envenomates the brain of its host the American cockroach (Periplaneta americana), thereby making it a behaviorally compliant food supply for its offspring. The target of venom injection is a locomotory command center in the brain called the central complex. In this study, we investigate why stung cockroaches do not respond to injuries incurred during the manipulation process by the wasp. In particular, we examine how envenomation compromises nociceptive signaling pathways in the host. Noxious stimuli applied to the cuticle of stung cockroaches fail to evoke escape responses, even though nociceptive interneurons projecting to the brain respond normally. Hence, while nociceptive signals are carried forward to the brain, they fail to trigger robust nocifensive behavior. Electrophysiological recordings from the central complex of stung animals demonstrate decreases in peak firing rate, total firing, and duration of noxious-evoked activity. The single parameter best correlated with altered noxious-evoked behavioral responses of stung cockroaches is reduced duration of the evoked response in the central complex. Our findings demonstrate how the reproductive strategy of a parasitoid wasp is served by venom-mediated elimination of aversive, nocifensive behavior in its host.
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spelling pubmed-94119362022-08-27 Suppression of host nocifensive behavior by parasitoid wasp venom Rana, Amit Emanuel, Stav Adams, Michael E. Libersat, Frederic Front Physiol Physiology The parasitoid wasp Ampulex compressa envenomates the brain of its host the American cockroach (Periplaneta americana), thereby making it a behaviorally compliant food supply for its offspring. The target of venom injection is a locomotory command center in the brain called the central complex. In this study, we investigate why stung cockroaches do not respond to injuries incurred during the manipulation process by the wasp. In particular, we examine how envenomation compromises nociceptive signaling pathways in the host. Noxious stimuli applied to the cuticle of stung cockroaches fail to evoke escape responses, even though nociceptive interneurons projecting to the brain respond normally. Hence, while nociceptive signals are carried forward to the brain, they fail to trigger robust nocifensive behavior. Electrophysiological recordings from the central complex of stung animals demonstrate decreases in peak firing rate, total firing, and duration of noxious-evoked activity. The single parameter best correlated with altered noxious-evoked behavioral responses of stung cockroaches is reduced duration of the evoked response in the central complex. Our findings demonstrate how the reproductive strategy of a parasitoid wasp is served by venom-mediated elimination of aversive, nocifensive behavior in its host. Frontiers Media S.A. 2022-08-12 /pmc/articles/PMC9411936/ /pubmed/36035493 http://dx.doi.org/10.3389/fphys.2022.907041 Text en Copyright © 2022 Rana, Emanuel, Adams and Libersat. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Rana, Amit
Emanuel, Stav
Adams, Michael E.
Libersat, Frederic
Suppression of host nocifensive behavior by parasitoid wasp venom
title Suppression of host nocifensive behavior by parasitoid wasp venom
title_full Suppression of host nocifensive behavior by parasitoid wasp venom
title_fullStr Suppression of host nocifensive behavior by parasitoid wasp venom
title_full_unstemmed Suppression of host nocifensive behavior by parasitoid wasp venom
title_short Suppression of host nocifensive behavior by parasitoid wasp venom
title_sort suppression of host nocifensive behavior by parasitoid wasp venom
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411936/
https://www.ncbi.nlm.nih.gov/pubmed/36035493
http://dx.doi.org/10.3389/fphys.2022.907041
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