Cargando…

Clinicopathologic features and biologic behavior of canine splenic nodules with stromal, histiocytic and lymphoid components

The term fibrohistiocytic nodule has been discouraged in favor of specific pathologic entities, including complex nodular hyperplasia, splenic stromal sarcoma and histiocytic sarcoma. Nevertheless, the diagnosis of splenic lesions with mixed stromal, histiocytic and lymphoid components still remains...

Descripción completa

Detalles Bibliográficos
Autores principales: Sabattini, Silvia, Rigillo, Antonella, Foiani, Greta, Marconato, Laura, Vascellari, Marta, Greco, Alessandra, Agnoli, Chiara, Annoni, Maurizio, Melchiotti, Erica, Campigli, Michela, Benali, Silvia Lucia, Bettini, Giuliano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411940/
https://www.ncbi.nlm.nih.gov/pubmed/36032303
http://dx.doi.org/10.3389/fvets.2022.962685
_version_ 1784775378460475392
author Sabattini, Silvia
Rigillo, Antonella
Foiani, Greta
Marconato, Laura
Vascellari, Marta
Greco, Alessandra
Agnoli, Chiara
Annoni, Maurizio
Melchiotti, Erica
Campigli, Michela
Benali, Silvia Lucia
Bettini, Giuliano
author_facet Sabattini, Silvia
Rigillo, Antonella
Foiani, Greta
Marconato, Laura
Vascellari, Marta
Greco, Alessandra
Agnoli, Chiara
Annoni, Maurizio
Melchiotti, Erica
Campigli, Michela
Benali, Silvia Lucia
Bettini, Giuliano
author_sort Sabattini, Silvia
collection PubMed
description The term fibrohistiocytic nodule has been discouraged in favor of specific pathologic entities, including complex nodular hyperplasia, splenic stromal sarcoma and histiocytic sarcoma. Nevertheless, the diagnosis of splenic lesions with mixed stromal, histiocytic and lymphoid components still remains a challenge due to lack of straightforward histologic criteria. Misestimation of the biologic behavior of these lesions may lead to detrimental consequences on the clinical management of patients. In this study, we retrospectively evaluated the clinicopathologic features and outcome of canine splenic nodular lesions with mixed components, to identify prognostic factors and histologic criteria of malignancy. Thirty-seven cases were included. Immunohistochemistry did not allow for further subclassification. Nine (24.3%) dogs died from disease-related causes after a median of 234 days (range, 48–1,247). One-, 2- and 3-year disease-specific survival rates were 80, 60, and 43%, respectively. When considering nodules with stromal cell atypia and at least one of mitotic count ≥9, presence of karyomegaly/multinucleated cells and lymphoid component <40%, half of these dogs died of disease-related causes with a median disease-specific survival time of 548 days (95% CI, 0-1216). In the remaining dogs, no disease-related death was reported (P < 0.001). Canine splenic nodular lesions with mixed stromal, histiocytic and lymphoid components and histologic criteria of malignancy may behave aggressively, leading to distant metastasis and death. In the absence of further criteria aiding their classification, and to better characterize their biologic behavior, we encourage the distinction of these complex splenic tumors from conventional sarcomas and histiocytic sarcomas.
format Online
Article
Text
id pubmed-9411940
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-94119402022-08-27 Clinicopathologic features and biologic behavior of canine splenic nodules with stromal, histiocytic and lymphoid components Sabattini, Silvia Rigillo, Antonella Foiani, Greta Marconato, Laura Vascellari, Marta Greco, Alessandra Agnoli, Chiara Annoni, Maurizio Melchiotti, Erica Campigli, Michela Benali, Silvia Lucia Bettini, Giuliano Front Vet Sci Veterinary Science The term fibrohistiocytic nodule has been discouraged in favor of specific pathologic entities, including complex nodular hyperplasia, splenic stromal sarcoma and histiocytic sarcoma. Nevertheless, the diagnosis of splenic lesions with mixed stromal, histiocytic and lymphoid components still remains a challenge due to lack of straightforward histologic criteria. Misestimation of the biologic behavior of these lesions may lead to detrimental consequences on the clinical management of patients. In this study, we retrospectively evaluated the clinicopathologic features and outcome of canine splenic nodular lesions with mixed components, to identify prognostic factors and histologic criteria of malignancy. Thirty-seven cases were included. Immunohistochemistry did not allow for further subclassification. Nine (24.3%) dogs died from disease-related causes after a median of 234 days (range, 48–1,247). One-, 2- and 3-year disease-specific survival rates were 80, 60, and 43%, respectively. When considering nodules with stromal cell atypia and at least one of mitotic count ≥9, presence of karyomegaly/multinucleated cells and lymphoid component <40%, half of these dogs died of disease-related causes with a median disease-specific survival time of 548 days (95% CI, 0-1216). In the remaining dogs, no disease-related death was reported (P < 0.001). Canine splenic nodular lesions with mixed stromal, histiocytic and lymphoid components and histologic criteria of malignancy may behave aggressively, leading to distant metastasis and death. In the absence of further criteria aiding their classification, and to better characterize their biologic behavior, we encourage the distinction of these complex splenic tumors from conventional sarcomas and histiocytic sarcomas. Frontiers Media S.A. 2022-08-12 /pmc/articles/PMC9411940/ /pubmed/36032303 http://dx.doi.org/10.3389/fvets.2022.962685 Text en Copyright © 2022 Sabattini, Rigillo, Foiani, Marconato, Vascellari, Greco, Agnoli, Annoni, Melchiotti, Campigli, Benali and Bettini. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Sabattini, Silvia
Rigillo, Antonella
Foiani, Greta
Marconato, Laura
Vascellari, Marta
Greco, Alessandra
Agnoli, Chiara
Annoni, Maurizio
Melchiotti, Erica
Campigli, Michela
Benali, Silvia Lucia
Bettini, Giuliano
Clinicopathologic features and biologic behavior of canine splenic nodules with stromal, histiocytic and lymphoid components
title Clinicopathologic features and biologic behavior of canine splenic nodules with stromal, histiocytic and lymphoid components
title_full Clinicopathologic features and biologic behavior of canine splenic nodules with stromal, histiocytic and lymphoid components
title_fullStr Clinicopathologic features and biologic behavior of canine splenic nodules with stromal, histiocytic and lymphoid components
title_full_unstemmed Clinicopathologic features and biologic behavior of canine splenic nodules with stromal, histiocytic and lymphoid components
title_short Clinicopathologic features and biologic behavior of canine splenic nodules with stromal, histiocytic and lymphoid components
title_sort clinicopathologic features and biologic behavior of canine splenic nodules with stromal, histiocytic and lymphoid components
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411940/
https://www.ncbi.nlm.nih.gov/pubmed/36032303
http://dx.doi.org/10.3389/fvets.2022.962685
work_keys_str_mv AT sabattinisilvia clinicopathologicfeaturesandbiologicbehaviorofcaninesplenicnoduleswithstromalhistiocyticandlymphoidcomponents
AT rigilloantonella clinicopathologicfeaturesandbiologicbehaviorofcaninesplenicnoduleswithstromalhistiocyticandlymphoidcomponents
AT foianigreta clinicopathologicfeaturesandbiologicbehaviorofcaninesplenicnoduleswithstromalhistiocyticandlymphoidcomponents
AT marconatolaura clinicopathologicfeaturesandbiologicbehaviorofcaninesplenicnoduleswithstromalhistiocyticandlymphoidcomponents
AT vascellarimarta clinicopathologicfeaturesandbiologicbehaviorofcaninesplenicnoduleswithstromalhistiocyticandlymphoidcomponents
AT grecoalessandra clinicopathologicfeaturesandbiologicbehaviorofcaninesplenicnoduleswithstromalhistiocyticandlymphoidcomponents
AT agnolichiara clinicopathologicfeaturesandbiologicbehaviorofcaninesplenicnoduleswithstromalhistiocyticandlymphoidcomponents
AT annonimaurizio clinicopathologicfeaturesandbiologicbehaviorofcaninesplenicnoduleswithstromalhistiocyticandlymphoidcomponents
AT melchiottierica clinicopathologicfeaturesandbiologicbehaviorofcaninesplenicnoduleswithstromalhistiocyticandlymphoidcomponents
AT campiglimichela clinicopathologicfeaturesandbiologicbehaviorofcaninesplenicnoduleswithstromalhistiocyticandlymphoidcomponents
AT benalisilvialucia clinicopathologicfeaturesandbiologicbehaviorofcaninesplenicnoduleswithstromalhistiocyticandlymphoidcomponents
AT bettinigiuliano clinicopathologicfeaturesandbiologicbehaviorofcaninesplenicnoduleswithstromalhistiocyticandlymphoidcomponents