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Pan-immune-inflammation value is associated with the clinical stage of colorectal cancer

OBJECTIVE: We investigated the clinical significance of preoperative pan-immune-inflammation value (PIV) in patients with colorectal cancer (CRC). METHODS: In this retrospective study, 366 cases who underwent surgery for CRC were enrolled. Their clinical data were collected. PIV was calculated with...

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Autores principales: Zhao, HanZheng, Chen, Xingyu, Zhang, WenHui, Cheng, Die, Lu, Yanjie, Wang, Cheng, Li, JunHu, You, LiuPing, Yu, JiaYong, Guo, WenLong, Li, YuHong, Huang, YueNan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411960/
https://www.ncbi.nlm.nih.gov/pubmed/36034356
http://dx.doi.org/10.3389/fsurg.2022.996844
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author Zhao, HanZheng
Chen, Xingyu
Zhang, WenHui
Cheng, Die
Lu, Yanjie
Wang, Cheng
Li, JunHu
You, LiuPing
Yu, JiaYong
Guo, WenLong
Li, YuHong
Huang, YueNan
author_facet Zhao, HanZheng
Chen, Xingyu
Zhang, WenHui
Cheng, Die
Lu, Yanjie
Wang, Cheng
Li, JunHu
You, LiuPing
Yu, JiaYong
Guo, WenLong
Li, YuHong
Huang, YueNan
author_sort Zhao, HanZheng
collection PubMed
description OBJECTIVE: We investigated the clinical significance of preoperative pan-immune-inflammation value (PIV) in patients with colorectal cancer (CRC). METHODS: In this retrospective study, 366 cases who underwent surgery for CRC were enrolled. Their clinical data were collected. PIV was calculated with the formula PIV = [neutrophil count (10(9)/L)× platelet count (10(9)/L) × monocyte count (10(9)/L) /lymphocyte count (10(9)/L). Patients were divided into high PIV (> median PIV) and low PIV (< median PIV) groups. The relationship between PIV and clinicopathological features of CRC was investigated. Receiver operating characteristic (ROC) curve was plotted to indicate the value of immune-inflammatory biomarkers (IIBs) in predicting the TNM stage of CRC, and the area under the curve (AUC) was calculated to evaluate the actual clinical value of IIBs. AUC > 0.5 and closer to 1 indicated the better predictive efficacy. The influencing factors of PIV in CRC were analyzed. RESULTS: We found that PIV was positively correlated with tumor size (r = 0.300, p < 0.05), carcinoembryonic antigen (CEA) (r = 0.214, p < 0.05) and carbohydrate antigen 125 (CA-125) (r = 0.249, p < 0.05), but negatively correlated with albumin (Alb) (r = −0.242, p < 0.05). PIV was significantly different in patients with different tumor locations (left or right), surgical methods (laparotomy versus laparoscopic surgery) (p < 0.05), and patients with different pathological T stages, N-stage and TNM stages (p < 0.05). ROC curve analysis of IIBs showed the AUC of PIV was greater than other markers when combined with CEA or carbohydrate antigen 19–9 (CA19–9). Multivariate regression analysis identified T stage, CEA, Alb, and tumor size as the independent influential factors of PIV in CRC. CONCLUSION: PIV is associated with the tumor stage in patients with CRC, which may be useful in preoperative assessment of CRC.
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spelling pubmed-94119602022-08-27 Pan-immune-inflammation value is associated with the clinical stage of colorectal cancer Zhao, HanZheng Chen, Xingyu Zhang, WenHui Cheng, Die Lu, Yanjie Wang, Cheng Li, JunHu You, LiuPing Yu, JiaYong Guo, WenLong Li, YuHong Huang, YueNan Front Surg Surgery OBJECTIVE: We investigated the clinical significance of preoperative pan-immune-inflammation value (PIV) in patients with colorectal cancer (CRC). METHODS: In this retrospective study, 366 cases who underwent surgery for CRC were enrolled. Their clinical data were collected. PIV was calculated with the formula PIV = [neutrophil count (10(9)/L)× platelet count (10(9)/L) × monocyte count (10(9)/L) /lymphocyte count (10(9)/L). Patients were divided into high PIV (> median PIV) and low PIV (< median PIV) groups. The relationship between PIV and clinicopathological features of CRC was investigated. Receiver operating characteristic (ROC) curve was plotted to indicate the value of immune-inflammatory biomarkers (IIBs) in predicting the TNM stage of CRC, and the area under the curve (AUC) was calculated to evaluate the actual clinical value of IIBs. AUC > 0.5 and closer to 1 indicated the better predictive efficacy. The influencing factors of PIV in CRC were analyzed. RESULTS: We found that PIV was positively correlated with tumor size (r = 0.300, p < 0.05), carcinoembryonic antigen (CEA) (r = 0.214, p < 0.05) and carbohydrate antigen 125 (CA-125) (r = 0.249, p < 0.05), but negatively correlated with albumin (Alb) (r = −0.242, p < 0.05). PIV was significantly different in patients with different tumor locations (left or right), surgical methods (laparotomy versus laparoscopic surgery) (p < 0.05), and patients with different pathological T stages, N-stage and TNM stages (p < 0.05). ROC curve analysis of IIBs showed the AUC of PIV was greater than other markers when combined with CEA or carbohydrate antigen 19–9 (CA19–9). Multivariate regression analysis identified T stage, CEA, Alb, and tumor size as the independent influential factors of PIV in CRC. CONCLUSION: PIV is associated with the tumor stage in patients with CRC, which may be useful in preoperative assessment of CRC. Frontiers Media S.A. 2022-08-12 /pmc/articles/PMC9411960/ /pubmed/36034356 http://dx.doi.org/10.3389/fsurg.2022.996844 Text en © 2022 Zhao, Chen, Zhang, Cheng, Lu, Wang, Li, You, Yu, Guo, Li and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Zhao, HanZheng
Chen, Xingyu
Zhang, WenHui
Cheng, Die
Lu, Yanjie
Wang, Cheng
Li, JunHu
You, LiuPing
Yu, JiaYong
Guo, WenLong
Li, YuHong
Huang, YueNan
Pan-immune-inflammation value is associated with the clinical stage of colorectal cancer
title Pan-immune-inflammation value is associated with the clinical stage of colorectal cancer
title_full Pan-immune-inflammation value is associated with the clinical stage of colorectal cancer
title_fullStr Pan-immune-inflammation value is associated with the clinical stage of colorectal cancer
title_full_unstemmed Pan-immune-inflammation value is associated with the clinical stage of colorectal cancer
title_short Pan-immune-inflammation value is associated with the clinical stage of colorectal cancer
title_sort pan-immune-inflammation value is associated with the clinical stage of colorectal cancer
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411960/
https://www.ncbi.nlm.nih.gov/pubmed/36034356
http://dx.doi.org/10.3389/fsurg.2022.996844
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