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Progress in murine models of ruptured abdominal aortic aneurysm

Abdominal aortic aneurysm (AAA) is a focal dilation of the aorta that is prevalent in aged populations. The progressive and unpredictable expansion of AAA could result in aneurysmal rupture, which is associated with ~80% mortality. Due to the expanded screening efforts and progress in diagnostic too...

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Autores principales: Yin, Li, Kent, Eric William, Wang, Bowen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411998/
https://www.ncbi.nlm.nih.gov/pubmed/36035911
http://dx.doi.org/10.3389/fcvm.2022.950018
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author Yin, Li
Kent, Eric William
Wang, Bowen
author_facet Yin, Li
Kent, Eric William
Wang, Bowen
author_sort Yin, Li
collection PubMed
description Abdominal aortic aneurysm (AAA) is a focal dilation of the aorta that is prevalent in aged populations. The progressive and unpredictable expansion of AAA could result in aneurysmal rupture, which is associated with ~80% mortality. Due to the expanded screening efforts and progress in diagnostic tools, an ever-increasing amount of asymptomatic AAA patients are being identified yet without a cure to stop the rampant aortic expansion. A key barrier that hinders the development of effective AAA treatment is our incomplete understanding of the cellular and molecular basis of its pathogenesis and progression into rupture. Animal models provide invaluable mechanistic insights into AAA pathophysiology. However, there is no single experimental model that completely recapitulate the complex biology behind AAA, and different AAA-inducing methodologies are associated with distinct disease course and rupture rate. In this review article, we summarize the established murine models of ruptured AAA and discuss their respective strengths and utilities.
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spelling pubmed-94119982022-08-27 Progress in murine models of ruptured abdominal aortic aneurysm Yin, Li Kent, Eric William Wang, Bowen Front Cardiovasc Med Cardiovascular Medicine Abdominal aortic aneurysm (AAA) is a focal dilation of the aorta that is prevalent in aged populations. The progressive and unpredictable expansion of AAA could result in aneurysmal rupture, which is associated with ~80% mortality. Due to the expanded screening efforts and progress in diagnostic tools, an ever-increasing amount of asymptomatic AAA patients are being identified yet without a cure to stop the rampant aortic expansion. A key barrier that hinders the development of effective AAA treatment is our incomplete understanding of the cellular and molecular basis of its pathogenesis and progression into rupture. Animal models provide invaluable mechanistic insights into AAA pathophysiology. However, there is no single experimental model that completely recapitulate the complex biology behind AAA, and different AAA-inducing methodologies are associated with distinct disease course and rupture rate. In this review article, we summarize the established murine models of ruptured AAA and discuss their respective strengths and utilities. Frontiers Media S.A. 2022-08-12 /pmc/articles/PMC9411998/ /pubmed/36035911 http://dx.doi.org/10.3389/fcvm.2022.950018 Text en Copyright © 2022 Yin, Kent and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Yin, Li
Kent, Eric William
Wang, Bowen
Progress in murine models of ruptured abdominal aortic aneurysm
title Progress in murine models of ruptured abdominal aortic aneurysm
title_full Progress in murine models of ruptured abdominal aortic aneurysm
title_fullStr Progress in murine models of ruptured abdominal aortic aneurysm
title_full_unstemmed Progress in murine models of ruptured abdominal aortic aneurysm
title_short Progress in murine models of ruptured abdominal aortic aneurysm
title_sort progress in murine models of ruptured abdominal aortic aneurysm
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411998/
https://www.ncbi.nlm.nih.gov/pubmed/36035911
http://dx.doi.org/10.3389/fcvm.2022.950018
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