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Training machine learning models with synthetic data improves the prediction of ventricular origin in outflow tract ventricular arrhythmias

In order to determine the site of origin (SOO) in outflow tract ventricular arrhythmias (OTVAs) before an ablation procedure, several algorithms based on manual identification of electrocardiogram (ECG) features, have been developed. However, the reported accuracy decreases when tested with differen...

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Autores principales: Doste, Ruben, Lozano, Miguel, Jimenez-Perez, Guillermo, Mont, Lluis, Berruezo, Antonio, Penela, Diego, Camara, Oscar, Sebastian, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412034/
https://www.ncbi.nlm.nih.gov/pubmed/36035489
http://dx.doi.org/10.3389/fphys.2022.909372
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author Doste, Ruben
Lozano, Miguel
Jimenez-Perez, Guillermo
Mont, Lluis
Berruezo, Antonio
Penela, Diego
Camara, Oscar
Sebastian, Rafael
author_facet Doste, Ruben
Lozano, Miguel
Jimenez-Perez, Guillermo
Mont, Lluis
Berruezo, Antonio
Penela, Diego
Camara, Oscar
Sebastian, Rafael
author_sort Doste, Ruben
collection PubMed
description In order to determine the site of origin (SOO) in outflow tract ventricular arrhythmias (OTVAs) before an ablation procedure, several algorithms based on manual identification of electrocardiogram (ECG) features, have been developed. However, the reported accuracy decreases when tested with different datasets. Machine learning algorithms can automatize the process and improve generalization, but their performance is hampered by the lack of large enough OTVA databases. We propose the use of detailed electrophysiological simulations of OTVAs to train a machine learning classification model to predict the ventricular origin of the SOO of ectopic beats. We generated a synthetic database of 12-lead ECGs (2,496 signals) by running multiple simulations from the most typical OTVA SOO in 16 patient-specific geometries. Two types of input data were considered in the classification, raw and feature ECG signals. From the simulated raw 12-lead ECG, we analyzed the contribution of each lead in the predictions, keeping the best ones for the training process. For feature-based analysis, we used entropy-based methods to rank the obtained features. A cross-validation process was included to evaluate the machine learning model. Following, two clinical OTVA databases from different hospitals, including ECGs from 365 patients, were used as test-sets to assess the generalization of the proposed approach. The results show that V2 was the best lead for classification. Prediction of the SOO in OTVA, using both raw signals or features for classification, presented high accuracy values (>0.96). Generalization of the network trained on simulated data was good for both patient datasets (accuracy of 0.86 and 0.84, respectively) and presented better values than using exclusively real ECGs for classification (accuracy of 0.84 and 0.76 for each dataset). The use of simulated ECG data for training machine learning-based classification algorithms is critical to obtain good SOO predictions in OTVA compared to real data alone. The fast implementation and generalization of the proposed methodology may contribute towards its application to a clinical routine.
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spelling pubmed-94120342022-08-27 Training machine learning models with synthetic data improves the prediction of ventricular origin in outflow tract ventricular arrhythmias Doste, Ruben Lozano, Miguel Jimenez-Perez, Guillermo Mont, Lluis Berruezo, Antonio Penela, Diego Camara, Oscar Sebastian, Rafael Front Physiol Physiology In order to determine the site of origin (SOO) in outflow tract ventricular arrhythmias (OTVAs) before an ablation procedure, several algorithms based on manual identification of electrocardiogram (ECG) features, have been developed. However, the reported accuracy decreases when tested with different datasets. Machine learning algorithms can automatize the process and improve generalization, but their performance is hampered by the lack of large enough OTVA databases. We propose the use of detailed electrophysiological simulations of OTVAs to train a machine learning classification model to predict the ventricular origin of the SOO of ectopic beats. We generated a synthetic database of 12-lead ECGs (2,496 signals) by running multiple simulations from the most typical OTVA SOO in 16 patient-specific geometries. Two types of input data were considered in the classification, raw and feature ECG signals. From the simulated raw 12-lead ECG, we analyzed the contribution of each lead in the predictions, keeping the best ones for the training process. For feature-based analysis, we used entropy-based methods to rank the obtained features. A cross-validation process was included to evaluate the machine learning model. Following, two clinical OTVA databases from different hospitals, including ECGs from 365 patients, were used as test-sets to assess the generalization of the proposed approach. The results show that V2 was the best lead for classification. Prediction of the SOO in OTVA, using both raw signals or features for classification, presented high accuracy values (>0.96). Generalization of the network trained on simulated data was good for both patient datasets (accuracy of 0.86 and 0.84, respectively) and presented better values than using exclusively real ECGs for classification (accuracy of 0.84 and 0.76 for each dataset). The use of simulated ECG data for training machine learning-based classification algorithms is critical to obtain good SOO predictions in OTVA compared to real data alone. The fast implementation and generalization of the proposed methodology may contribute towards its application to a clinical routine. Frontiers Media S.A. 2022-08-12 /pmc/articles/PMC9412034/ /pubmed/36035489 http://dx.doi.org/10.3389/fphys.2022.909372 Text en Copyright © 2022 Doste, Lozano, Jimenez-Perez, Mont, Berruezo, Penela, Camara and Sebastian. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Doste, Ruben
Lozano, Miguel
Jimenez-Perez, Guillermo
Mont, Lluis
Berruezo, Antonio
Penela, Diego
Camara, Oscar
Sebastian, Rafael
Training machine learning models with synthetic data improves the prediction of ventricular origin in outflow tract ventricular arrhythmias
title Training machine learning models with synthetic data improves the prediction of ventricular origin in outflow tract ventricular arrhythmias
title_full Training machine learning models with synthetic data improves the prediction of ventricular origin in outflow tract ventricular arrhythmias
title_fullStr Training machine learning models with synthetic data improves the prediction of ventricular origin in outflow tract ventricular arrhythmias
title_full_unstemmed Training machine learning models with synthetic data improves the prediction of ventricular origin in outflow tract ventricular arrhythmias
title_short Training machine learning models with synthetic data improves the prediction of ventricular origin in outflow tract ventricular arrhythmias
title_sort training machine learning models with synthetic data improves the prediction of ventricular origin in outflow tract ventricular arrhythmias
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412034/
https://www.ncbi.nlm.nih.gov/pubmed/36035489
http://dx.doi.org/10.3389/fphys.2022.909372
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