Cargando…

Clinical evaluation of toll-like receptor-5 agonist for radiation-induced oral mucositis in beagle dogs

This study aimed to evaluate the clinical safety and validate the radiomitigative effect of KMRC011, against radiation-induced oral mucositis in beagle dogs. Clinical safety was evaluated by assessing tolerability, complete blood tests, and plasma biochemistry after drug administration. The radiomit...

Descripción completa

Detalles Bibliográficos
Autores principales: Ko, Jaeeun, Kim, Jaehwan, Choi, Yang-Kyu, Nahm, Sang-Soep, Kim, Jayon, Seo, Sun-Min, Seo, Jin-Seok, Lee, Woojong, Chung, Weon Kuu, Eom, Kidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412099/
https://www.ncbi.nlm.nih.gov/pubmed/36032288
http://dx.doi.org/10.3389/fvets.2022.839467
_version_ 1784775415654514688
author Ko, Jaeeun
Kim, Jaehwan
Choi, Yang-Kyu
Nahm, Sang-Soep
Kim, Jayon
Seo, Sun-Min
Seo, Jin-Seok
Lee, Woojong
Chung, Weon Kuu
Eom, Kidong
author_facet Ko, Jaeeun
Kim, Jaehwan
Choi, Yang-Kyu
Nahm, Sang-Soep
Kim, Jayon
Seo, Sun-Min
Seo, Jin-Seok
Lee, Woojong
Chung, Weon Kuu
Eom, Kidong
author_sort Ko, Jaeeun
collection PubMed
description This study aimed to evaluate the clinical safety and validate the radiomitigative effect of KMRC011, against radiation-induced oral mucositis in beagle dogs. Clinical safety was evaluated by assessing tolerability, complete blood tests, and plasma biochemistry after drug administration. The radiomitigative effect of KMRC011 was evaluated macropathologically and histopathologically after inducing oral mucositis iatrogenically using 20 Gy irradiation. The plasma concentration of interleukin-6 was measured via enzyme-linked immunosorbent assay, as a biomarker of KMRC011 bioreactivity. Decreased tolerability, increased neutrophil count, hepatic enzyme concentration, C-reactive protein concentration, and interleukin-6 concentration after the administration was observed and ceased within 24 h without additional treatment. Although all animals included in the present study developed severe mucositis in the late course of the study, animals administered KMRC011 showed less erythema, ulcer, inflammatory infiltration. These results suggest that KMRC011 may be used as an adjuvant for radiotherapy without severe adverse effects, especially during short-term radiotherapy, such as hypofractionated radiotherapy or stereotactic radiotherapy.
format Online
Article
Text
id pubmed-9412099
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-94120992022-08-27 Clinical evaluation of toll-like receptor-5 agonist for radiation-induced oral mucositis in beagle dogs Ko, Jaeeun Kim, Jaehwan Choi, Yang-Kyu Nahm, Sang-Soep Kim, Jayon Seo, Sun-Min Seo, Jin-Seok Lee, Woojong Chung, Weon Kuu Eom, Kidong Front Vet Sci Veterinary Science This study aimed to evaluate the clinical safety and validate the radiomitigative effect of KMRC011, against radiation-induced oral mucositis in beagle dogs. Clinical safety was evaluated by assessing tolerability, complete blood tests, and plasma biochemistry after drug administration. The radiomitigative effect of KMRC011 was evaluated macropathologically and histopathologically after inducing oral mucositis iatrogenically using 20 Gy irradiation. The plasma concentration of interleukin-6 was measured via enzyme-linked immunosorbent assay, as a biomarker of KMRC011 bioreactivity. Decreased tolerability, increased neutrophil count, hepatic enzyme concentration, C-reactive protein concentration, and interleukin-6 concentration after the administration was observed and ceased within 24 h without additional treatment. Although all animals included in the present study developed severe mucositis in the late course of the study, animals administered KMRC011 showed less erythema, ulcer, inflammatory infiltration. These results suggest that KMRC011 may be used as an adjuvant for radiotherapy without severe adverse effects, especially during short-term radiotherapy, such as hypofractionated radiotherapy or stereotactic radiotherapy. Frontiers Media S.A. 2022-08-12 /pmc/articles/PMC9412099/ /pubmed/36032288 http://dx.doi.org/10.3389/fvets.2022.839467 Text en Copyright © 2022 Ko, Kim, Choi, Nahm, Kim, Seo, Seo, Lee, Chung and Eom. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Ko, Jaeeun
Kim, Jaehwan
Choi, Yang-Kyu
Nahm, Sang-Soep
Kim, Jayon
Seo, Sun-Min
Seo, Jin-Seok
Lee, Woojong
Chung, Weon Kuu
Eom, Kidong
Clinical evaluation of toll-like receptor-5 agonist for radiation-induced oral mucositis in beagle dogs
title Clinical evaluation of toll-like receptor-5 agonist for radiation-induced oral mucositis in beagle dogs
title_full Clinical evaluation of toll-like receptor-5 agonist for radiation-induced oral mucositis in beagle dogs
title_fullStr Clinical evaluation of toll-like receptor-5 agonist for radiation-induced oral mucositis in beagle dogs
title_full_unstemmed Clinical evaluation of toll-like receptor-5 agonist for radiation-induced oral mucositis in beagle dogs
title_short Clinical evaluation of toll-like receptor-5 agonist for radiation-induced oral mucositis in beagle dogs
title_sort clinical evaluation of toll-like receptor-5 agonist for radiation-induced oral mucositis in beagle dogs
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412099/
https://www.ncbi.nlm.nih.gov/pubmed/36032288
http://dx.doi.org/10.3389/fvets.2022.839467
work_keys_str_mv AT kojaeeun clinicalevaluationoftolllikereceptor5agonistforradiationinducedoralmucositisinbeagledogs
AT kimjaehwan clinicalevaluationoftolllikereceptor5agonistforradiationinducedoralmucositisinbeagledogs
AT choiyangkyu clinicalevaluationoftolllikereceptor5agonistforradiationinducedoralmucositisinbeagledogs
AT nahmsangsoep clinicalevaluationoftolllikereceptor5agonistforradiationinducedoralmucositisinbeagledogs
AT kimjayon clinicalevaluationoftolllikereceptor5agonistforradiationinducedoralmucositisinbeagledogs
AT seosunmin clinicalevaluationoftolllikereceptor5agonistforradiationinducedoralmucositisinbeagledogs
AT seojinseok clinicalevaluationoftolllikereceptor5agonistforradiationinducedoralmucositisinbeagledogs
AT leewoojong clinicalevaluationoftolllikereceptor5agonistforradiationinducedoralmucositisinbeagledogs
AT chungweonkuu clinicalevaluationoftolllikereceptor5agonistforradiationinducedoralmucositisinbeagledogs
AT eomkidong clinicalevaluationoftolllikereceptor5agonistforradiationinducedoralmucositisinbeagledogs