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Clinical evaluation of toll-like receptor-5 agonist for radiation-induced oral mucositis in beagle dogs
This study aimed to evaluate the clinical safety and validate the radiomitigative effect of KMRC011, against radiation-induced oral mucositis in beagle dogs. Clinical safety was evaluated by assessing tolerability, complete blood tests, and plasma biochemistry after drug administration. The radiomit...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412099/ https://www.ncbi.nlm.nih.gov/pubmed/36032288 http://dx.doi.org/10.3389/fvets.2022.839467 |
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author | Ko, Jaeeun Kim, Jaehwan Choi, Yang-Kyu Nahm, Sang-Soep Kim, Jayon Seo, Sun-Min Seo, Jin-Seok Lee, Woojong Chung, Weon Kuu Eom, Kidong |
author_facet | Ko, Jaeeun Kim, Jaehwan Choi, Yang-Kyu Nahm, Sang-Soep Kim, Jayon Seo, Sun-Min Seo, Jin-Seok Lee, Woojong Chung, Weon Kuu Eom, Kidong |
author_sort | Ko, Jaeeun |
collection | PubMed |
description | This study aimed to evaluate the clinical safety and validate the radiomitigative effect of KMRC011, against radiation-induced oral mucositis in beagle dogs. Clinical safety was evaluated by assessing tolerability, complete blood tests, and plasma biochemistry after drug administration. The radiomitigative effect of KMRC011 was evaluated macropathologically and histopathologically after inducing oral mucositis iatrogenically using 20 Gy irradiation. The plasma concentration of interleukin-6 was measured via enzyme-linked immunosorbent assay, as a biomarker of KMRC011 bioreactivity. Decreased tolerability, increased neutrophil count, hepatic enzyme concentration, C-reactive protein concentration, and interleukin-6 concentration after the administration was observed and ceased within 24 h without additional treatment. Although all animals included in the present study developed severe mucositis in the late course of the study, animals administered KMRC011 showed less erythema, ulcer, inflammatory infiltration. These results suggest that KMRC011 may be used as an adjuvant for radiotherapy without severe adverse effects, especially during short-term radiotherapy, such as hypofractionated radiotherapy or stereotactic radiotherapy. |
format | Online Article Text |
id | pubmed-9412099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94120992022-08-27 Clinical evaluation of toll-like receptor-5 agonist for radiation-induced oral mucositis in beagle dogs Ko, Jaeeun Kim, Jaehwan Choi, Yang-Kyu Nahm, Sang-Soep Kim, Jayon Seo, Sun-Min Seo, Jin-Seok Lee, Woojong Chung, Weon Kuu Eom, Kidong Front Vet Sci Veterinary Science This study aimed to evaluate the clinical safety and validate the radiomitigative effect of KMRC011, against radiation-induced oral mucositis in beagle dogs. Clinical safety was evaluated by assessing tolerability, complete blood tests, and plasma biochemistry after drug administration. The radiomitigative effect of KMRC011 was evaluated macropathologically and histopathologically after inducing oral mucositis iatrogenically using 20 Gy irradiation. The plasma concentration of interleukin-6 was measured via enzyme-linked immunosorbent assay, as a biomarker of KMRC011 bioreactivity. Decreased tolerability, increased neutrophil count, hepatic enzyme concentration, C-reactive protein concentration, and interleukin-6 concentration after the administration was observed and ceased within 24 h without additional treatment. Although all animals included in the present study developed severe mucositis in the late course of the study, animals administered KMRC011 showed less erythema, ulcer, inflammatory infiltration. These results suggest that KMRC011 may be used as an adjuvant for radiotherapy without severe adverse effects, especially during short-term radiotherapy, such as hypofractionated radiotherapy or stereotactic radiotherapy. Frontiers Media S.A. 2022-08-12 /pmc/articles/PMC9412099/ /pubmed/36032288 http://dx.doi.org/10.3389/fvets.2022.839467 Text en Copyright © 2022 Ko, Kim, Choi, Nahm, Kim, Seo, Seo, Lee, Chung and Eom. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Veterinary Science Ko, Jaeeun Kim, Jaehwan Choi, Yang-Kyu Nahm, Sang-Soep Kim, Jayon Seo, Sun-Min Seo, Jin-Seok Lee, Woojong Chung, Weon Kuu Eom, Kidong Clinical evaluation of toll-like receptor-5 agonist for radiation-induced oral mucositis in beagle dogs |
title | Clinical evaluation of toll-like receptor-5 agonist for radiation-induced oral mucositis in beagle dogs |
title_full | Clinical evaluation of toll-like receptor-5 agonist for radiation-induced oral mucositis in beagle dogs |
title_fullStr | Clinical evaluation of toll-like receptor-5 agonist for radiation-induced oral mucositis in beagle dogs |
title_full_unstemmed | Clinical evaluation of toll-like receptor-5 agonist for radiation-induced oral mucositis in beagle dogs |
title_short | Clinical evaluation of toll-like receptor-5 agonist for radiation-induced oral mucositis in beagle dogs |
title_sort | clinical evaluation of toll-like receptor-5 agonist for radiation-induced oral mucositis in beagle dogs |
topic | Veterinary Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412099/ https://www.ncbi.nlm.nih.gov/pubmed/36032288 http://dx.doi.org/10.3389/fvets.2022.839467 |
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