Are Non-animal Systemic Safety Assessments Protective? A Toolbox and Workflow

An important question in toxicological risk assessment is whether non-animal new approach methodologies (NAMs) can be used to make safety decisions that are protective of human health, without being overly conservative. In this work, we propose a core NAM toolbox and workflow for conducting systemic...

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Detalles Bibliográficos
Autores principales: Middleton, Alistair M, Reynolds, Joe, Cable, Sophie, Baltazar, Maria Teresa, Li, Hequn, Bevan, Samantha, Carmichael, Paul L, Dent, Matthew Philip, Hatherell, Sarah, Houghton, Jade, Kukic, Predrag, Liddell, Mark, Malcomber, Sophie, Nicol, Beate, Park, Benjamin, Patel, Hiral, Scott, Sharon, Sparham, Chris, Walker, Paul, White, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Regulatory Science, Risk Assessment, and Decision Making
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412174/
https://www.ncbi.nlm.nih.gov/pubmed/35822611
http://dx.doi.org/10.1093/toxsci/kfac068

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