Cargando…

Design, Synthesis, and Characterization of Novel Coordination Compounds of Benzimidazole Derivatives with Cadmium

Four complexes of Cd(II) with benzimidazole derivatives were synthesized and named C1, C2, C3, and C4. All coordination compounds were characterized through elemental analysis (EA), flame atomic absorption spectrometry (FAAS), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysi...

Descripción completa

Detalles Bibliográficos
Autores principales: Raducka, Anita, Świątkowski, Marcin, Korona-Głowniak, Izabela, Kaproń, Barbara, Plech, Tomasz, Szczesio, Małgorzata, Gobis, Katarzyna, Czylkowska, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412362/
https://www.ncbi.nlm.nih.gov/pubmed/36015252
http://dx.doi.org/10.3390/pharmaceutics14081626
_version_ 1784775475310100480
author Raducka, Anita
Świątkowski, Marcin
Korona-Głowniak, Izabela
Kaproń, Barbara
Plech, Tomasz
Szczesio, Małgorzata
Gobis, Katarzyna
Czylkowska, Agnieszka
author_facet Raducka, Anita
Świątkowski, Marcin
Korona-Głowniak, Izabela
Kaproń, Barbara
Plech, Tomasz
Szczesio, Małgorzata
Gobis, Katarzyna
Czylkowska, Agnieszka
author_sort Raducka, Anita
collection PubMed
description Four complexes of Cd(II) with benzimidazole derivatives were synthesized and named C1, C2, C3, and C4. All coordination compounds were characterized through elemental analysis (EA), flame atomic absorption spectrometry (FAAS), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis coupled with mass spectrometry) (TG-MS), a cytotoxicity assay (MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide)), and computational chemical analysis for absorption, distribution, metabolism, and excretion (ADME). All of the obtained results are compatible and are consistent with the respective structures of the obtained compounds and their properties. The various techniques used allowed the determination of the composition, proposed structure of the compounds, their thermal stability and thermal properties, and the method of coordination between the metal (II) ion and the ligand. The ADME technique was also used to estimate the physicochemical and biological properties. The antitumor activity of the compounds was determined with an MTT assay on the glioblastoma (T98G), neuroblastoma (SK-N-AS), and lung adenocarcinoma (A549) cell lines, as well as normal human skin fibroblasts (CCD-1059Sk). Compound C2 was found to have potential antitumor properties and to be effective in inhibiting the growth of neuroblastoma cells. The antimicrobial activity of Cd complexes, free ligands, and reference drugs was tested against six strains of Gram-positive bacteria, five strains of Gram-negative rods, and three strains of yeasts. Compound C3 significantly increased activity against Gram-positive bacteria in comparison to the ligand.
format Online
Article
Text
id pubmed-9412362
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-94123622022-08-27 Design, Synthesis, and Characterization of Novel Coordination Compounds of Benzimidazole Derivatives with Cadmium Raducka, Anita Świątkowski, Marcin Korona-Głowniak, Izabela Kaproń, Barbara Plech, Tomasz Szczesio, Małgorzata Gobis, Katarzyna Czylkowska, Agnieszka Pharmaceutics Article Four complexes of Cd(II) with benzimidazole derivatives were synthesized and named C1, C2, C3, and C4. All coordination compounds were characterized through elemental analysis (EA), flame atomic absorption spectrometry (FAAS), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis coupled with mass spectrometry) (TG-MS), a cytotoxicity assay (MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide)), and computational chemical analysis for absorption, distribution, metabolism, and excretion (ADME). All of the obtained results are compatible and are consistent with the respective structures of the obtained compounds and their properties. The various techniques used allowed the determination of the composition, proposed structure of the compounds, their thermal stability and thermal properties, and the method of coordination between the metal (II) ion and the ligand. The ADME technique was also used to estimate the physicochemical and biological properties. The antitumor activity of the compounds was determined with an MTT assay on the glioblastoma (T98G), neuroblastoma (SK-N-AS), and lung adenocarcinoma (A549) cell lines, as well as normal human skin fibroblasts (CCD-1059Sk). Compound C2 was found to have potential antitumor properties and to be effective in inhibiting the growth of neuroblastoma cells. The antimicrobial activity of Cd complexes, free ligands, and reference drugs was tested against six strains of Gram-positive bacteria, five strains of Gram-negative rods, and three strains of yeasts. Compound C3 significantly increased activity against Gram-positive bacteria in comparison to the ligand. MDPI 2022-08-03 /pmc/articles/PMC9412362/ /pubmed/36015252 http://dx.doi.org/10.3390/pharmaceutics14081626 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Raducka, Anita
Świątkowski, Marcin
Korona-Głowniak, Izabela
Kaproń, Barbara
Plech, Tomasz
Szczesio, Małgorzata
Gobis, Katarzyna
Czylkowska, Agnieszka
Design, Synthesis, and Characterization of Novel Coordination Compounds of Benzimidazole Derivatives with Cadmium
title Design, Synthesis, and Characterization of Novel Coordination Compounds of Benzimidazole Derivatives with Cadmium
title_full Design, Synthesis, and Characterization of Novel Coordination Compounds of Benzimidazole Derivatives with Cadmium
title_fullStr Design, Synthesis, and Characterization of Novel Coordination Compounds of Benzimidazole Derivatives with Cadmium
title_full_unstemmed Design, Synthesis, and Characterization of Novel Coordination Compounds of Benzimidazole Derivatives with Cadmium
title_short Design, Synthesis, and Characterization of Novel Coordination Compounds of Benzimidazole Derivatives with Cadmium
title_sort design, synthesis, and characterization of novel coordination compounds of benzimidazole derivatives with cadmium
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412362/
https://www.ncbi.nlm.nih.gov/pubmed/36015252
http://dx.doi.org/10.3390/pharmaceutics14081626
work_keys_str_mv AT raduckaanita designsynthesisandcharacterizationofnovelcoordinationcompoundsofbenzimidazolederivativeswithcadmium
AT swiatkowskimarcin designsynthesisandcharacterizationofnovelcoordinationcompoundsofbenzimidazolederivativeswithcadmium
AT koronagłowniakizabela designsynthesisandcharacterizationofnovelcoordinationcompoundsofbenzimidazolederivativeswithcadmium
AT kapronbarbara designsynthesisandcharacterizationofnovelcoordinationcompoundsofbenzimidazolederivativeswithcadmium
AT plechtomasz designsynthesisandcharacterizationofnovelcoordinationcompoundsofbenzimidazolederivativeswithcadmium
AT szczesiomałgorzata designsynthesisandcharacterizationofnovelcoordinationcompoundsofbenzimidazolederivativeswithcadmium
AT gobiskatarzyna designsynthesisandcharacterizationofnovelcoordinationcompoundsofbenzimidazolederivativeswithcadmium
AT czylkowskaagnieszka designsynthesisandcharacterizationofnovelcoordinationcompoundsofbenzimidazolederivativeswithcadmium