Design, Synthesis, and Development of pyrazolo[1,5-a]pyrimidine Derivatives as a Novel Series of Selective PI3Kδ Inhibitors: Part I—Indole Derivatives

Phosphoinositide 3-kinase δ (PI3Kδ), a member of the class I PI3K family, is an essential signaling biomolecule that regulates the differentiation, proliferation, migration, and survival of immune cells. The overactivity of this protein causes cellular dysfunctions in many human disorders, for examp...

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Detalles Bibliográficos
Autores principales: Stypik, Mariola, Zagozda, Marcin, Michałek, Stanisław, Dymek, Barbara, Zdżalik-Bielecka, Daria, Dziachan, Maciej, Orłowska, Nina, Gunerka, Paweł, Turowski, Paweł, Hucz-Kalitowska, Joanna, Stańczak, Aleksandra, Stańczak, Paulina, Mulewski, Krzysztof, Smuga, Damian, Stefaniak, Filip, Gurba-Bryśkiewicz, Lidia, Leniak, Arkadiusz, Ochal, Zbigniew, Mach, Mateusz, Dzwonek, Karolina, Lamparska-Przybysz, Monika, Dubiel, Krzysztof, Wieczorek, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412374/
https://www.ncbi.nlm.nih.gov/pubmed/36015098
http://dx.doi.org/10.3390/ph15080949

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