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Relationships between Milk and Blood Biochemical Parameters and Metabolic Status in Dairy Cows during Lactation

This study aimed to determine blood and milk metabolic parameters and their correlations for the purpose of evaluating metabolic status in dairy cows. Blood and milk samples were collected from 100 Holstein dairy cows during morning milking. The cows were allocated to four groups according to the pr...

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Autores principales: Andjelić, Biljana, Djoković, Radojica, Cincović, Marko, Bogosavljević-Bošković, Snežana, Petrović, Milun, Mladenović, Jelena, Čukić, Aleksandar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412388/
https://www.ncbi.nlm.nih.gov/pubmed/36005606
http://dx.doi.org/10.3390/metabo12080733
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author Andjelić, Biljana
Djoković, Radojica
Cincović, Marko
Bogosavljević-Bošković, Snežana
Petrović, Milun
Mladenović, Jelena
Čukić, Aleksandar
author_facet Andjelić, Biljana
Djoković, Radojica
Cincović, Marko
Bogosavljević-Bošković, Snežana
Petrović, Milun
Mladenović, Jelena
Čukić, Aleksandar
author_sort Andjelić, Biljana
collection PubMed
description This study aimed to determine blood and milk metabolic parameters and their correlations for the purpose of evaluating metabolic status in dairy cows. Blood and milk samples were collected from 100 Holstein dairy cows during morning milking. The cows were allocated to four groups according to the production period, including cows in early (n = 18), full (n = 26), mid (n = 25) and late (n = 31) lactation. The value of non-esterified fatty acids (NEFA), β-hydroxybutyrate (BHB), glucose, triglycerides (TG), total cholesterol (TChol), total protein (TP), albumin, globulin, urea, total bilirubin (TBil), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), and lactate dexydrogenase (LDH) in the blood were determined. The following milk parameters were measured: fat, protein, lactose, urea, AST, ALT, ALP, GGT, LDH and BHB. Blood serum NEFA, BHB, TBil, AST, ALT, ALP and LDH were higher in early lactation cows, whereas glucose, TP, globulin and urea levels were significantly lower in early lactation cows. Milk fat and lactose levels were lower in early lactation cows, whereas milk protein and the activities of AST, ALT, ALP and LDH in milk were highly greater in early lactation cows. Milk fat was positively correlated with glucose, TP and TG, and negatively correlated with BHB, NEFA, TBil, ALT, LDH and ALP levels in the blood. Enzyme activities in milk were positively correlated with those in blood and with blood NEFA, BHB and TBil levels, and negatively correlated with blood glucose, TChol and TG. A significant positive correlation existed between blood and milk BHB values. Many correlations showed the same slope during all lactation periods. In conclusion, similar changes in blood and milk metabolite concentration during lactation and milk to blood correlations confirm that milk has great potential in predicting of blood metabolites and metabolic status of cows.
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spelling pubmed-94123882022-08-27 Relationships between Milk and Blood Biochemical Parameters and Metabolic Status in Dairy Cows during Lactation Andjelić, Biljana Djoković, Radojica Cincović, Marko Bogosavljević-Bošković, Snežana Petrović, Milun Mladenović, Jelena Čukić, Aleksandar Metabolites Article This study aimed to determine blood and milk metabolic parameters and their correlations for the purpose of evaluating metabolic status in dairy cows. Blood and milk samples were collected from 100 Holstein dairy cows during morning milking. The cows were allocated to four groups according to the production period, including cows in early (n = 18), full (n = 26), mid (n = 25) and late (n = 31) lactation. The value of non-esterified fatty acids (NEFA), β-hydroxybutyrate (BHB), glucose, triglycerides (TG), total cholesterol (TChol), total protein (TP), albumin, globulin, urea, total bilirubin (TBil), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), and lactate dexydrogenase (LDH) in the blood were determined. The following milk parameters were measured: fat, protein, lactose, urea, AST, ALT, ALP, GGT, LDH and BHB. Blood serum NEFA, BHB, TBil, AST, ALT, ALP and LDH were higher in early lactation cows, whereas glucose, TP, globulin and urea levels were significantly lower in early lactation cows. Milk fat and lactose levels were lower in early lactation cows, whereas milk protein and the activities of AST, ALT, ALP and LDH in milk were highly greater in early lactation cows. Milk fat was positively correlated with glucose, TP and TG, and negatively correlated with BHB, NEFA, TBil, ALT, LDH and ALP levels in the blood. Enzyme activities in milk were positively correlated with those in blood and with blood NEFA, BHB and TBil levels, and negatively correlated with blood glucose, TChol and TG. A significant positive correlation existed between blood and milk BHB values. Many correlations showed the same slope during all lactation periods. In conclusion, similar changes in blood and milk metabolite concentration during lactation and milk to blood correlations confirm that milk has great potential in predicting of blood metabolites and metabolic status of cows. MDPI 2022-08-09 /pmc/articles/PMC9412388/ /pubmed/36005606 http://dx.doi.org/10.3390/metabo12080733 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Andjelić, Biljana
Djoković, Radojica
Cincović, Marko
Bogosavljević-Bošković, Snežana
Petrović, Milun
Mladenović, Jelena
Čukić, Aleksandar
Relationships between Milk and Blood Biochemical Parameters and Metabolic Status in Dairy Cows during Lactation
title Relationships between Milk and Blood Biochemical Parameters and Metabolic Status in Dairy Cows during Lactation
title_full Relationships between Milk and Blood Biochemical Parameters and Metabolic Status in Dairy Cows during Lactation
title_fullStr Relationships between Milk and Blood Biochemical Parameters and Metabolic Status in Dairy Cows during Lactation
title_full_unstemmed Relationships between Milk and Blood Biochemical Parameters and Metabolic Status in Dairy Cows during Lactation
title_short Relationships between Milk and Blood Biochemical Parameters and Metabolic Status in Dairy Cows during Lactation
title_sort relationships between milk and blood biochemical parameters and metabolic status in dairy cows during lactation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412388/
https://www.ncbi.nlm.nih.gov/pubmed/36005606
http://dx.doi.org/10.3390/metabo12080733
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