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An Optical Modeling Framework for Coronavirus Detection Using Graphene-Based Nanosensor

The outbreak of the COVID-19 virus has faced the world with a new and dangerous challenge due to its contagious nature. Hence, developing sensory technologies to detect the coronavirus rapidly can provide a favorable condition for pandemic control of dangerous diseases. In between, because of the na...

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Autores principales: Maghoul, Amir, Simonsen, Ingve, Rostami, Ali, Mirtaheri, Peyman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412525/
https://www.ncbi.nlm.nih.gov/pubmed/36014733
http://dx.doi.org/10.3390/nano12162868
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author Maghoul, Amir
Simonsen, Ingve
Rostami, Ali
Mirtaheri, Peyman
author_facet Maghoul, Amir
Simonsen, Ingve
Rostami, Ali
Mirtaheri, Peyman
author_sort Maghoul, Amir
collection PubMed
description The outbreak of the COVID-19 virus has faced the world with a new and dangerous challenge due to its contagious nature. Hence, developing sensory technologies to detect the coronavirus rapidly can provide a favorable condition for pandemic control of dangerous diseases. In between, because of the nanoscale size of this virus, there is a need for a good understanding of its optical behavior, which can give an extraordinary insight into the more efficient design of sensory devices. For the first time, this paper presents an optical modeling framework for a COVID-19 particle in the blood and extracts its optical characteristics based on numerical computations. To this end, a theoretical foundation of a COVID-19 particle is proposed based on the most recent experimental results available in the literature to simulate the optical behavior of the coronavirus under varying physical conditions. In order to obtain the optical properties of the COVID-19 model, the light reflectance by the structure is then simulated for different geometrical sizes, including the diameter of the COVID-19 particle and the size of the spikes surrounding it. It is found that the reflectance spectra are very sensitive to geometric changes of the coronavirus. Furthermore, the density of COVID-19 particles is investigated when the light is incident on different sides of the sample. Following this, we propose a nanosensor based on graphene, silicon, and gold nanodisks and demonstrate the functionality of the designed devices for detecting COVID-19 particles inside the blood samples. Indeed, the presented nanosensor design can be promoted as a practical procedure for creating nanoelectronic kits and wearable devices with considerable potential for fast virus detection.
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spelling pubmed-94125252022-08-27 An Optical Modeling Framework for Coronavirus Detection Using Graphene-Based Nanosensor Maghoul, Amir Simonsen, Ingve Rostami, Ali Mirtaheri, Peyman Nanomaterials (Basel) Article The outbreak of the COVID-19 virus has faced the world with a new and dangerous challenge due to its contagious nature. Hence, developing sensory technologies to detect the coronavirus rapidly can provide a favorable condition for pandemic control of dangerous diseases. In between, because of the nanoscale size of this virus, there is a need for a good understanding of its optical behavior, which can give an extraordinary insight into the more efficient design of sensory devices. For the first time, this paper presents an optical modeling framework for a COVID-19 particle in the blood and extracts its optical characteristics based on numerical computations. To this end, a theoretical foundation of a COVID-19 particle is proposed based on the most recent experimental results available in the literature to simulate the optical behavior of the coronavirus under varying physical conditions. In order to obtain the optical properties of the COVID-19 model, the light reflectance by the structure is then simulated for different geometrical sizes, including the diameter of the COVID-19 particle and the size of the spikes surrounding it. It is found that the reflectance spectra are very sensitive to geometric changes of the coronavirus. Furthermore, the density of COVID-19 particles is investigated when the light is incident on different sides of the sample. Following this, we propose a nanosensor based on graphene, silicon, and gold nanodisks and demonstrate the functionality of the designed devices for detecting COVID-19 particles inside the blood samples. Indeed, the presented nanosensor design can be promoted as a practical procedure for creating nanoelectronic kits and wearable devices with considerable potential for fast virus detection. MDPI 2022-08-20 /pmc/articles/PMC9412525/ /pubmed/36014733 http://dx.doi.org/10.3390/nano12162868 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Maghoul, Amir
Simonsen, Ingve
Rostami, Ali
Mirtaheri, Peyman
An Optical Modeling Framework for Coronavirus Detection Using Graphene-Based Nanosensor
title An Optical Modeling Framework for Coronavirus Detection Using Graphene-Based Nanosensor
title_full An Optical Modeling Framework for Coronavirus Detection Using Graphene-Based Nanosensor
title_fullStr An Optical Modeling Framework for Coronavirus Detection Using Graphene-Based Nanosensor
title_full_unstemmed An Optical Modeling Framework for Coronavirus Detection Using Graphene-Based Nanosensor
title_short An Optical Modeling Framework for Coronavirus Detection Using Graphene-Based Nanosensor
title_sort optical modeling framework for coronavirus detection using graphene-based nanosensor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412525/
https://www.ncbi.nlm.nih.gov/pubmed/36014733
http://dx.doi.org/10.3390/nano12162868
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