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Sesquiterpenoids from Inula britannica and Their Potential Effects against Triple-Negative Breast Cancer Cells
Flowers of Inula britannica commercially serve as pharmaceutical herbs in the manufacturing of medicinal products. In the current study, sesquiterpenoids of I. britannica flowers’ extract and their potential effects against triple-negative breast cancer (TNBC) cells were investigated. Eight structur...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412570/ https://www.ncbi.nlm.nih.gov/pubmed/36014473 http://dx.doi.org/10.3390/molecules27165230 |
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author | Qi, Ruo-Yu Guo, Cong Peng, Xiao-Na Tang, Jiang-Jiang |
author_facet | Qi, Ruo-Yu Guo, Cong Peng, Xiao-Na Tang, Jiang-Jiang |
author_sort | Qi, Ruo-Yu |
collection | PubMed |
description | Flowers of Inula britannica commercially serve as pharmaceutical herbs in the manufacturing of medicinal products. In the current study, sesquiterpenoids of I. britannica flowers’ extract and their potential effects against triple-negative breast cancer (TNBC) cells were investigated. Eight structurally diverse sesquiterpenoids, including one sesquiterpenoid dimer (1) and seven sesquiterpenoid monomers (2–8) were isolated from this source. The structures of all compounds were elucidated by 1D/2D NMR data, and their absolute configurations were discerned by single crystal X-ray diffraction. All of the compounds were tested for their potential effects against TNBC. Specifically, 5 displayed strong antiproliferative potency against TNBC cells with a high selective index (SI) on MCF-7 cells (SI > 4 of IC(50) on MDA-MB-468/IC(50) on MCF-7), and dimer 1 (IC(50) = 8.82 ± 0.85 μM) showed better antiproliferative potency against MCF-7 cells than the other monomers did (2–8) (IC(50) > 20 μM). To our best knowledge, compound 5 is the first sesquiterpenoid targeting TNBC cells. |
format | Online Article Text |
id | pubmed-9412570 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94125702022-08-27 Sesquiterpenoids from Inula britannica and Their Potential Effects against Triple-Negative Breast Cancer Cells Qi, Ruo-Yu Guo, Cong Peng, Xiao-Na Tang, Jiang-Jiang Molecules Article Flowers of Inula britannica commercially serve as pharmaceutical herbs in the manufacturing of medicinal products. In the current study, sesquiterpenoids of I. britannica flowers’ extract and their potential effects against triple-negative breast cancer (TNBC) cells were investigated. Eight structurally diverse sesquiterpenoids, including one sesquiterpenoid dimer (1) and seven sesquiterpenoid monomers (2–8) were isolated from this source. The structures of all compounds were elucidated by 1D/2D NMR data, and their absolute configurations were discerned by single crystal X-ray diffraction. All of the compounds were tested for their potential effects against TNBC. Specifically, 5 displayed strong antiproliferative potency against TNBC cells with a high selective index (SI) on MCF-7 cells (SI > 4 of IC(50) on MDA-MB-468/IC(50) on MCF-7), and dimer 1 (IC(50) = 8.82 ± 0.85 μM) showed better antiproliferative potency against MCF-7 cells than the other monomers did (2–8) (IC(50) > 20 μM). To our best knowledge, compound 5 is the first sesquiterpenoid targeting TNBC cells. MDPI 2022-08-16 /pmc/articles/PMC9412570/ /pubmed/36014473 http://dx.doi.org/10.3390/molecules27165230 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Qi, Ruo-Yu Guo, Cong Peng, Xiao-Na Tang, Jiang-Jiang Sesquiterpenoids from Inula britannica and Their Potential Effects against Triple-Negative Breast Cancer Cells |
title | Sesquiterpenoids from Inula britannica and Their Potential Effects against Triple-Negative Breast Cancer Cells |
title_full | Sesquiterpenoids from Inula britannica and Their Potential Effects against Triple-Negative Breast Cancer Cells |
title_fullStr | Sesquiterpenoids from Inula britannica and Their Potential Effects against Triple-Negative Breast Cancer Cells |
title_full_unstemmed | Sesquiterpenoids from Inula britannica and Their Potential Effects against Triple-Negative Breast Cancer Cells |
title_short | Sesquiterpenoids from Inula britannica and Their Potential Effects against Triple-Negative Breast Cancer Cells |
title_sort | sesquiterpenoids from inula britannica and their potential effects against triple-negative breast cancer cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412570/ https://www.ncbi.nlm.nih.gov/pubmed/36014473 http://dx.doi.org/10.3390/molecules27165230 |
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