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Central Composite Optimization of Glycerosomes for the Enhanced Oral Bioavailability and Brain Delivery of Quetiapine Fumarate
This study aimed to formulate and statistically optimize glycerosomal formulations of Quetiapine fumarate (QTF) to increase its oral bioavailability and enhance its brain delivery. The study was designed using a Central composite rotatable design using Design-Expert(®) software. The independent vari...
Autores principales: | Zaki, Randa Mohammed, Alfadhel, Munerah M., Alossaimi, Manal A., Elsawaf, Lara Ayman, Devanathadesikan Seshadri, Vidya, Almurshedi, Alanood S., Yusif, Rehab Mohammad, Said, Mayada |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412614/ https://www.ncbi.nlm.nih.gov/pubmed/36015089 http://dx.doi.org/10.3390/ph15080940 |
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