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Renal Leukemic Infiltration Overlapping Acute Focal Bacterial Nephritis during Myelodysplastic Syndrome: An Autopsy Case Report

Renal leukemic infiltration is uncommon in myeloid neoplasms, including myelodysplastic syndromes (MDS). A 76-year-old male patient was admitted to our hospital with complaints of fever and dyspnea. He was diagnosed with MDS with multilineage dysplasia and acute focal bacterial nephritis (AFBN) base...

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Autores principales: Murakami, Keishu, Tamura, Shinobu, Maruyama, Anna, Naitoh, Tomomi, Teramoto, Kan, Mikasa, Yurina, Tanaka, Masaoh, Murata, Shinichi, Kato, Seiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412618/
https://www.ncbi.nlm.nih.gov/pubmed/36013527
http://dx.doi.org/10.3390/medicina58081060
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author Murakami, Keishu
Tamura, Shinobu
Maruyama, Anna
Naitoh, Tomomi
Teramoto, Kan
Mikasa, Yurina
Tanaka, Masaoh
Murata, Shinichi
Kato, Seiya
author_facet Murakami, Keishu
Tamura, Shinobu
Maruyama, Anna
Naitoh, Tomomi
Teramoto, Kan
Mikasa, Yurina
Tanaka, Masaoh
Murata, Shinichi
Kato, Seiya
author_sort Murakami, Keishu
collection PubMed
description Renal leukemic infiltration is uncommon in myeloid neoplasms, including myelodysplastic syndromes (MDS). A 76-year-old male patient was admitted to our hospital with complaints of fever and dyspnea. He was diagnosed with MDS with multilineage dysplasia and acute focal bacterial nephritis (AFBN) based on clinical, laboratory, and radiological investigations. Antibiotic treatment temporarily improved his condition, but the radiological image of AFBN remained. His condition gradually deteriorated into multiple organ failure, and he unfortunately died on the 31st day of hospitalization. Autopsy findings revealed significantly increased p53-positive blasts in the bone marrow and renal parenchyma overlapping AFBN, suggesting leukemic transformation and renal infiltration. This case emphasizes the need to review the diagnosis when antibiotic treatment is ineffective in MDS patients with AFBN.
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spelling pubmed-94126182022-08-27 Renal Leukemic Infiltration Overlapping Acute Focal Bacterial Nephritis during Myelodysplastic Syndrome: An Autopsy Case Report Murakami, Keishu Tamura, Shinobu Maruyama, Anna Naitoh, Tomomi Teramoto, Kan Mikasa, Yurina Tanaka, Masaoh Murata, Shinichi Kato, Seiya Medicina (Kaunas) Case Report Renal leukemic infiltration is uncommon in myeloid neoplasms, including myelodysplastic syndromes (MDS). A 76-year-old male patient was admitted to our hospital with complaints of fever and dyspnea. He was diagnosed with MDS with multilineage dysplasia and acute focal bacterial nephritis (AFBN) based on clinical, laboratory, and radiological investigations. Antibiotic treatment temporarily improved his condition, but the radiological image of AFBN remained. His condition gradually deteriorated into multiple organ failure, and he unfortunately died on the 31st day of hospitalization. Autopsy findings revealed significantly increased p53-positive blasts in the bone marrow and renal parenchyma overlapping AFBN, suggesting leukemic transformation and renal infiltration. This case emphasizes the need to review the diagnosis when antibiotic treatment is ineffective in MDS patients with AFBN. MDPI 2022-08-05 /pmc/articles/PMC9412618/ /pubmed/36013527 http://dx.doi.org/10.3390/medicina58081060 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Murakami, Keishu
Tamura, Shinobu
Maruyama, Anna
Naitoh, Tomomi
Teramoto, Kan
Mikasa, Yurina
Tanaka, Masaoh
Murata, Shinichi
Kato, Seiya
Renal Leukemic Infiltration Overlapping Acute Focal Bacterial Nephritis during Myelodysplastic Syndrome: An Autopsy Case Report
title Renal Leukemic Infiltration Overlapping Acute Focal Bacterial Nephritis during Myelodysplastic Syndrome: An Autopsy Case Report
title_full Renal Leukemic Infiltration Overlapping Acute Focal Bacterial Nephritis during Myelodysplastic Syndrome: An Autopsy Case Report
title_fullStr Renal Leukemic Infiltration Overlapping Acute Focal Bacterial Nephritis during Myelodysplastic Syndrome: An Autopsy Case Report
title_full_unstemmed Renal Leukemic Infiltration Overlapping Acute Focal Bacterial Nephritis during Myelodysplastic Syndrome: An Autopsy Case Report
title_short Renal Leukemic Infiltration Overlapping Acute Focal Bacterial Nephritis during Myelodysplastic Syndrome: An Autopsy Case Report
title_sort renal leukemic infiltration overlapping acute focal bacterial nephritis during myelodysplastic syndrome: an autopsy case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412618/
https://www.ncbi.nlm.nih.gov/pubmed/36013527
http://dx.doi.org/10.3390/medicina58081060
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