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Comparative Pathology of Zoonotic Orthopoxviruses
This review provides a brief history of the impacts that a human-specific Orthopoxvirus (OPXV), Variola virus, had on mankind, recalls how critical vaccination was for the eradication of this disease, and discusses the consequences of discontinuing vaccination against OPXV. One of these consequences...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412692/ https://www.ncbi.nlm.nih.gov/pubmed/36015017 http://dx.doi.org/10.3390/pathogens11080892 |
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author | MacNeill, Amy L. |
author_facet | MacNeill, Amy L. |
author_sort | MacNeill, Amy L. |
collection | PubMed |
description | This review provides a brief history of the impacts that a human-specific Orthopoxvirus (OPXV), Variola virus, had on mankind, recalls how critical vaccination was for the eradication of this disease, and discusses the consequences of discontinuing vaccination against OPXV. One of these consequences is the emergence of zoonotic OPXV diseases, including Monkeypox virus (MPXV). The focus of this manuscript is to compare pathology associated with zoonotic OPXV infection in veterinary species and in humans. Efficient recognition of poxvirus lesions and other, more subtle signs of disease in multiple species is critical to prevent further spread of poxvirus infections. Additionally included are a synopsis of the pathology observed in animal models of MPXV infection, the recent spread of MPXV among humans, and a discussion of the potential for this virus to persist in Europe and the Americas. |
format | Online Article Text |
id | pubmed-9412692 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94126922022-08-27 Comparative Pathology of Zoonotic Orthopoxviruses MacNeill, Amy L. Pathogens Review This review provides a brief history of the impacts that a human-specific Orthopoxvirus (OPXV), Variola virus, had on mankind, recalls how critical vaccination was for the eradication of this disease, and discusses the consequences of discontinuing vaccination against OPXV. One of these consequences is the emergence of zoonotic OPXV diseases, including Monkeypox virus (MPXV). The focus of this manuscript is to compare pathology associated with zoonotic OPXV infection in veterinary species and in humans. Efficient recognition of poxvirus lesions and other, more subtle signs of disease in multiple species is critical to prevent further spread of poxvirus infections. Additionally included are a synopsis of the pathology observed in animal models of MPXV infection, the recent spread of MPXV among humans, and a discussion of the potential for this virus to persist in Europe and the Americas. MDPI 2022-08-09 /pmc/articles/PMC9412692/ /pubmed/36015017 http://dx.doi.org/10.3390/pathogens11080892 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review MacNeill, Amy L. Comparative Pathology of Zoonotic Orthopoxviruses |
title | Comparative Pathology of Zoonotic Orthopoxviruses |
title_full | Comparative Pathology of Zoonotic Orthopoxviruses |
title_fullStr | Comparative Pathology of Zoonotic Orthopoxviruses |
title_full_unstemmed | Comparative Pathology of Zoonotic Orthopoxviruses |
title_short | Comparative Pathology of Zoonotic Orthopoxviruses |
title_sort | comparative pathology of zoonotic orthopoxviruses |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412692/ https://www.ncbi.nlm.nih.gov/pubmed/36015017 http://dx.doi.org/10.3390/pathogens11080892 |
work_keys_str_mv | AT macneillamyl comparativepathologyofzoonoticorthopoxviruses |