Cargando…
Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese
BACKGROUND: Hypertension (HTN) and type 2 diabetes mellitus (T2DM) are often coincident, and each condition is considered a risk factor for the other. Both occur frequently in the Inner Mongolia region of China. The reasons for differences in risk between Han and Mongolian ethnic groups are not know...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412857/ https://www.ncbi.nlm.nih.gov/pubmed/36159223 http://dx.doi.org/10.4239/wjd.v13.i8.643 |
_version_ | 1784775595658313728 |
---|---|
author | Zhao, Ke-Yu Yuan, Meng-Lu Wu, Yun-Na Cui, Hong-Wei Han, Wen-Yan Wang, Jing Su, Xiu-Lan |
author_facet | Zhao, Ke-Yu Yuan, Meng-Lu Wu, Yun-Na Cui, Hong-Wei Han, Wen-Yan Wang, Jing Su, Xiu-Lan |
author_sort | Zhao, Ke-Yu |
collection | PubMed |
description | BACKGROUND: Hypertension (HTN) and type 2 diabetes mellitus (T2DM) are often coincident, and each condition is considered a risk factor for the other. Both occur frequently in the Inner Mongolia region of China. The reasons for differences in risk between Han and Mongolian ethnic groups are not known. The LEPR gene and its polymorphism, rs1137101 (Gln223Arg), are both considered risk factors for HTN and T2DM, but any role of rs1137101 in the occurrence of HTN + T2DM remains unclear for Mongolian and Han populations in the Inner Mongolia region. AIM: To investigate the relationship between rs1137101 and the occurrence of HTN with T2DM in Mongolian and Han populations in Inner Mongolia. METHODS: A total of 2652 subjects of Han and Mongolian ethnic origins were enrolled in the current study, including 908 healthy controls, 1061 HTN patients and 683 HTN patients with T2DM. RESULTS: The association between the rs1137101 polymorphism and HTN with T2DM was analyzed, and differences between Han and Mongolian individuals assessed. There was a significant correlation between rs1137101 and HTN (co-dominant, dominant, over-dominant and log-additive models) and HTN + T2DM (co-dominant, dominant, over-dominant and log-additive models) after adjustment for sex and age in individuals of Mongolian origin. rs1137101 was significantly associated with HTN (co-dominant, recessive and log-additive models) and HTN + T2DM (co-dominant, dominant, over-dominant and log-additive models) in the Han Chinese population. CONCLUSION: Mongolian and Han subjects from Inner Mongolia with HTN who had rs1137101 were protected against the development of T2DM. Allele A has the opposite impact on the occurrence of HTN in Mongolian and Han Chinese populations. |
format | Online Article Text |
id | pubmed-9412857 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-94128572022-09-23 Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese Zhao, Ke-Yu Yuan, Meng-Lu Wu, Yun-Na Cui, Hong-Wei Han, Wen-Yan Wang, Jing Su, Xiu-Lan World J Diabetes Case Control Study BACKGROUND: Hypertension (HTN) and type 2 diabetes mellitus (T2DM) are often coincident, and each condition is considered a risk factor for the other. Both occur frequently in the Inner Mongolia region of China. The reasons for differences in risk between Han and Mongolian ethnic groups are not known. The LEPR gene and its polymorphism, rs1137101 (Gln223Arg), are both considered risk factors for HTN and T2DM, but any role of rs1137101 in the occurrence of HTN + T2DM remains unclear for Mongolian and Han populations in the Inner Mongolia region. AIM: To investigate the relationship between rs1137101 and the occurrence of HTN with T2DM in Mongolian and Han populations in Inner Mongolia. METHODS: A total of 2652 subjects of Han and Mongolian ethnic origins were enrolled in the current study, including 908 healthy controls, 1061 HTN patients and 683 HTN patients with T2DM. RESULTS: The association between the rs1137101 polymorphism and HTN with T2DM was analyzed, and differences between Han and Mongolian individuals assessed. There was a significant correlation between rs1137101 and HTN (co-dominant, dominant, over-dominant and log-additive models) and HTN + T2DM (co-dominant, dominant, over-dominant and log-additive models) after adjustment for sex and age in individuals of Mongolian origin. rs1137101 was significantly associated with HTN (co-dominant, recessive and log-additive models) and HTN + T2DM (co-dominant, dominant, over-dominant and log-additive models) in the Han Chinese population. CONCLUSION: Mongolian and Han subjects from Inner Mongolia with HTN who had rs1137101 were protected against the development of T2DM. Allele A has the opposite impact on the occurrence of HTN in Mongolian and Han Chinese populations. Baishideng Publishing Group Inc 2022-08-15 2022-08-15 /pmc/articles/PMC9412857/ /pubmed/36159223 http://dx.doi.org/10.4239/wjd.v13.i8.643 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Case Control Study Zhao, Ke-Yu Yuan, Meng-Lu Wu, Yun-Na Cui, Hong-Wei Han, Wen-Yan Wang, Jing Su, Xiu-Lan Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese |
title | Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese |
title_full | Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese |
title_fullStr | Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese |
title_full_unstemmed | Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese |
title_short | Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese |
title_sort | association of rs1137101 with hypertension and type 2 diabetes mellitus of mongolian and han chinese |
topic | Case Control Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412857/ https://www.ncbi.nlm.nih.gov/pubmed/36159223 http://dx.doi.org/10.4239/wjd.v13.i8.643 |
work_keys_str_mv | AT zhaokeyu associationofrs1137101withhypertensionandtype2diabetesmellitusofmongolianandhanchinese AT yuanmenglu associationofrs1137101withhypertensionandtype2diabetesmellitusofmongolianandhanchinese AT wuyunna associationofrs1137101withhypertensionandtype2diabetesmellitusofmongolianandhanchinese AT cuihongwei associationofrs1137101withhypertensionandtype2diabetesmellitusofmongolianandhanchinese AT hanwenyan associationofrs1137101withhypertensionandtype2diabetesmellitusofmongolianandhanchinese AT wangjing associationofrs1137101withhypertensionandtype2diabetesmellitusofmongolianandhanchinese AT suxiulan associationofrs1137101withhypertensionandtype2diabetesmellitusofmongolianandhanchinese |