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Angiogenesis in gastrointestinal stromal tumors: From bench to bedside
Gastrointestinal stromal tumors (GISTs) are rare neoplasms with an estimated incidence from 0.78 to 1-1.5 patients per 100000. They most commonly occur in the elderly during the eighth decade of life affecting predominantly the stomach, but also the small intestine, the omentum, mesentery and rectos...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412926/ https://www.ncbi.nlm.nih.gov/pubmed/36160752 http://dx.doi.org/10.4251/wjgo.v14.i8.1469 |
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author | Papadakos, Stavros P Tsagkaris, Christos Papadakis, Marios Papazoglou, Andreas S Moysidis, Dimitrios V Zografos, Constantinos G Theocharis, Stamatios |
author_facet | Papadakos, Stavros P Tsagkaris, Christos Papadakis, Marios Papazoglou, Andreas S Moysidis, Dimitrios V Zografos, Constantinos G Theocharis, Stamatios |
author_sort | Papadakos, Stavros P |
collection | PubMed |
description | Gastrointestinal stromal tumors (GISTs) are rare neoplasms with an estimated incidence from 0.78 to 1-1.5 patients per 100000. They most commonly occur in the elderly during the eighth decade of life affecting predominantly the stomach, but also the small intestine, the omentum, mesentery and rectosigmoid. The available treatments for GIST are associated with a significant rate of recurrent disease and adverse events. Thorough understanding of GIST’s pathophysiology and translation of this knowledge into novel regimens or drug repurposing is essential to counter this challenge. The present review summarizes the existing evidence about the role of angiogenesis in GIST’s development and progression and discusses its clinical underpinnings. |
format | Online Article Text |
id | pubmed-9412926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-94129262022-09-23 Angiogenesis in gastrointestinal stromal tumors: From bench to bedside Papadakos, Stavros P Tsagkaris, Christos Papadakis, Marios Papazoglou, Andreas S Moysidis, Dimitrios V Zografos, Constantinos G Theocharis, Stamatios World J Gastrointest Oncol Minireviews Gastrointestinal stromal tumors (GISTs) are rare neoplasms with an estimated incidence from 0.78 to 1-1.5 patients per 100000. They most commonly occur in the elderly during the eighth decade of life affecting predominantly the stomach, but also the small intestine, the omentum, mesentery and rectosigmoid. The available treatments for GIST are associated with a significant rate of recurrent disease and adverse events. Thorough understanding of GIST’s pathophysiology and translation of this knowledge into novel regimens or drug repurposing is essential to counter this challenge. The present review summarizes the existing evidence about the role of angiogenesis in GIST’s development and progression and discusses its clinical underpinnings. Baishideng Publishing Group Inc 2022-08-15 2022-08-15 /pmc/articles/PMC9412926/ /pubmed/36160752 http://dx.doi.org/10.4251/wjgo.v14.i8.1469 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Minireviews Papadakos, Stavros P Tsagkaris, Christos Papadakis, Marios Papazoglou, Andreas S Moysidis, Dimitrios V Zografos, Constantinos G Theocharis, Stamatios Angiogenesis in gastrointestinal stromal tumors: From bench to bedside |
title | Angiogenesis in gastrointestinal stromal tumors: From bench to bedside |
title_full | Angiogenesis in gastrointestinal stromal tumors: From bench to bedside |
title_fullStr | Angiogenesis in gastrointestinal stromal tumors: From bench to bedside |
title_full_unstemmed | Angiogenesis in gastrointestinal stromal tumors: From bench to bedside |
title_short | Angiogenesis in gastrointestinal stromal tumors: From bench to bedside |
title_sort | angiogenesis in gastrointestinal stromal tumors: from bench to bedside |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412926/ https://www.ncbi.nlm.nih.gov/pubmed/36160752 http://dx.doi.org/10.4251/wjgo.v14.i8.1469 |
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