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DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review

DNA in cells is frequently damaged by endogenous and exogenous agents. However, comprehensive mechanisms to combat and repair DNA damage have evolved to ensure genomic stability and integrity. Improper DNA damage repair may result in various diseases, including some types of tumors and autoimmune di...

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Detalles Bibliográficos
Autores principales: Wang, Menghui, Xie, Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412963/
https://www.ncbi.nlm.nih.gov/pubmed/36035159
http://dx.doi.org/10.3389/fgene.2022.931866
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author Wang, Menghui
Xie, Chuan
author_facet Wang, Menghui
Xie, Chuan
author_sort Wang, Menghui
collection PubMed
description DNA in cells is frequently damaged by endogenous and exogenous agents. However, comprehensive mechanisms to combat and repair DNA damage have evolved to ensure genomic stability and integrity. Improper DNA damage repair may result in various diseases, including some types of tumors and autoimmune diseases. Therefore, DNA damage repair mechanisms have been proposed as novel antitumor drug targets. To date, numerous drugs targeting DNA damage mechanisms have been developed. For example, PARP inhibitors that elicit synthetic lethality are widely used in individualized cancer therapies. In this review, we describe the latent DNA damage repair mechanisms in gastric cancer, the types of DNA damage that can contribute to the development of gastric cancer, and new therapeutic approaches for gastric cancer that target DNA damage repair pathways.
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spelling pubmed-94129632022-08-27 DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review Wang, Menghui Xie, Chuan Front Genet Genetics DNA in cells is frequently damaged by endogenous and exogenous agents. However, comprehensive mechanisms to combat and repair DNA damage have evolved to ensure genomic stability and integrity. Improper DNA damage repair may result in various diseases, including some types of tumors and autoimmune diseases. Therefore, DNA damage repair mechanisms have been proposed as novel antitumor drug targets. To date, numerous drugs targeting DNA damage mechanisms have been developed. For example, PARP inhibitors that elicit synthetic lethality are widely used in individualized cancer therapies. In this review, we describe the latent DNA damage repair mechanisms in gastric cancer, the types of DNA damage that can contribute to the development of gastric cancer, and new therapeutic approaches for gastric cancer that target DNA damage repair pathways. Frontiers Media S.A. 2022-08-12 /pmc/articles/PMC9412963/ /pubmed/36035159 http://dx.doi.org/10.3389/fgene.2022.931866 Text en Copyright © 2022 Wang and Xie. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Wang, Menghui
Xie, Chuan
DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review
title DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review
title_full DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review
title_fullStr DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review
title_full_unstemmed DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review
title_short DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review
title_sort dna damage repair and current therapeutic approaches in gastric cancer: a comprehensive review
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412963/
https://www.ncbi.nlm.nih.gov/pubmed/36035159
http://dx.doi.org/10.3389/fgene.2022.931866
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