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DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review
DNA in cells is frequently damaged by endogenous and exogenous agents. However, comprehensive mechanisms to combat and repair DNA damage have evolved to ensure genomic stability and integrity. Improper DNA damage repair may result in various diseases, including some types of tumors and autoimmune di...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412963/ https://www.ncbi.nlm.nih.gov/pubmed/36035159 http://dx.doi.org/10.3389/fgene.2022.931866 |
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author | Wang, Menghui Xie, Chuan |
author_facet | Wang, Menghui Xie, Chuan |
author_sort | Wang, Menghui |
collection | PubMed |
description | DNA in cells is frequently damaged by endogenous and exogenous agents. However, comprehensive mechanisms to combat and repair DNA damage have evolved to ensure genomic stability and integrity. Improper DNA damage repair may result in various diseases, including some types of tumors and autoimmune diseases. Therefore, DNA damage repair mechanisms have been proposed as novel antitumor drug targets. To date, numerous drugs targeting DNA damage mechanisms have been developed. For example, PARP inhibitors that elicit synthetic lethality are widely used in individualized cancer therapies. In this review, we describe the latent DNA damage repair mechanisms in gastric cancer, the types of DNA damage that can contribute to the development of gastric cancer, and new therapeutic approaches for gastric cancer that target DNA damage repair pathways. |
format | Online Article Text |
id | pubmed-9412963 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94129632022-08-27 DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review Wang, Menghui Xie, Chuan Front Genet Genetics DNA in cells is frequently damaged by endogenous and exogenous agents. However, comprehensive mechanisms to combat and repair DNA damage have evolved to ensure genomic stability and integrity. Improper DNA damage repair may result in various diseases, including some types of tumors and autoimmune diseases. Therefore, DNA damage repair mechanisms have been proposed as novel antitumor drug targets. To date, numerous drugs targeting DNA damage mechanisms have been developed. For example, PARP inhibitors that elicit synthetic lethality are widely used in individualized cancer therapies. In this review, we describe the latent DNA damage repair mechanisms in gastric cancer, the types of DNA damage that can contribute to the development of gastric cancer, and new therapeutic approaches for gastric cancer that target DNA damage repair pathways. Frontiers Media S.A. 2022-08-12 /pmc/articles/PMC9412963/ /pubmed/36035159 http://dx.doi.org/10.3389/fgene.2022.931866 Text en Copyright © 2022 Wang and Xie. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Wang, Menghui Xie, Chuan DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review |
title | DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review |
title_full | DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review |
title_fullStr | DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review |
title_full_unstemmed | DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review |
title_short | DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review |
title_sort | dna damage repair and current therapeutic approaches in gastric cancer: a comprehensive review |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412963/ https://www.ncbi.nlm.nih.gov/pubmed/36035159 http://dx.doi.org/10.3389/fgene.2022.931866 |
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