Comparison of the Blood–Brain Barrier Transport and Vulnerability to P-Glycoprotein-Mediated Drug–Drug Interaction of Domperidone versus Metoclopramide Assessed Using In Vitro Assay and PET Imaging

Domperidone and metoclopramide are widely prescribed antiemetic drugs with distinct neurological side effects. The impact of P-glycoprotein (P-gp)-mediated efflux at the blood–brain barrier (BBB) on brain exposure and BBB permeation was compared in vitro and in vivo using positron emission tomograph...

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Detalles Bibliográficos
Autores principales: Breuil, Louise, Goutal, Sébastien, Marie, Solène, Del Vecchio, Antonio, Audisio, Davide, Soyer, Amélie, Goislard, Maud, Saba, Wadad, Tournier, Nicolas, Caillé, Fabien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412994/
https://www.ncbi.nlm.nih.gov/pubmed/36015284
http://dx.doi.org/10.3390/pharmaceutics14081658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412994/
https://www.ncbi.nlm.nih.gov/pubmed/36015284
http://dx.doi.org/10.3390/pharmaceutics14081658

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