Molecular determinants of outcomes in meningiomas

Meningiomas are the most common intracranial primary tumor in adults. Surgery is the predominant therapeutic modality for symptomatic meningiomas. Although the majority of meningiomas are benign, there exists a subset of meningiomas that are clinically aggressive. Recent advances in genetics and epi...

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Autores principales: Lynes, John, Flores-Milan, Gabriel, Rubino, Sebastian, Arrington, John, Macaulay, Robert, Liu, James K. C., Beer-Furlan, Andre, Tran, Nam D., Vogelbaum, Michael A., Etame, Arnold B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413043/
https://www.ncbi.nlm.nih.gov/pubmed/36033542
http://dx.doi.org/10.3389/fonc.2022.962702
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author Lynes, John
Flores-Milan, Gabriel
Rubino, Sebastian
Arrington, John
Macaulay, Robert
Liu, James K. C.
Beer-Furlan, Andre
Tran, Nam D.
Vogelbaum, Michael A.
Etame, Arnold B.
author_facet Lynes, John
Flores-Milan, Gabriel
Rubino, Sebastian
Arrington, John
Macaulay, Robert
Liu, James K. C.
Beer-Furlan, Andre
Tran, Nam D.
Vogelbaum, Michael A.
Etame, Arnold B.
author_sort Lynes, John
collection PubMed
description Meningiomas are the most common intracranial primary tumor in adults. Surgery is the predominant therapeutic modality for symptomatic meningiomas. Although the majority of meningiomas are benign, there exists a subset of meningiomas that are clinically aggressive. Recent advances in genetics and epigenetics have uncovered molecular alterations that drive tumor meningioma biology with prognostic and therapeutic implications. In this review, we will discuss the advances on molecular determinants of therapeutic response in meningiomas to date and discuss findings of targeted therapies in meningiomas.
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spelling pubmed-94130432022-08-27 Molecular determinants of outcomes in meningiomas Lynes, John Flores-Milan, Gabriel Rubino, Sebastian Arrington, John Macaulay, Robert Liu, James K. C. Beer-Furlan, Andre Tran, Nam D. Vogelbaum, Michael A. Etame, Arnold B. Front Oncol Oncology Meningiomas are the most common intracranial primary tumor in adults. Surgery is the predominant therapeutic modality for symptomatic meningiomas. Although the majority of meningiomas are benign, there exists a subset of meningiomas that are clinically aggressive. Recent advances in genetics and epigenetics have uncovered molecular alterations that drive tumor meningioma biology with prognostic and therapeutic implications. In this review, we will discuss the advances on molecular determinants of therapeutic response in meningiomas to date and discuss findings of targeted therapies in meningiomas. Frontiers Media S.A. 2022-08-12 /pmc/articles/PMC9413043/ /pubmed/36033542 http://dx.doi.org/10.3389/fonc.2022.962702 Text en Copyright © 2022 Lynes, Flores-Milan, Rubino, Arrington, Macaulay, Liu, Beer-Furlan, Tran, Vogelbaum and Etame https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Lynes, John
Flores-Milan, Gabriel
Rubino, Sebastian
Arrington, John
Macaulay, Robert
Liu, James K. C.
Beer-Furlan, Andre
Tran, Nam D.
Vogelbaum, Michael A.
Etame, Arnold B.
Molecular determinants of outcomes in meningiomas
title Molecular determinants of outcomes in meningiomas
title_full Molecular determinants of outcomes in meningiomas
title_fullStr Molecular determinants of outcomes in meningiomas
title_full_unstemmed Molecular determinants of outcomes in meningiomas
title_short Molecular determinants of outcomes in meningiomas
title_sort molecular determinants of outcomes in meningiomas
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413043/
https://www.ncbi.nlm.nih.gov/pubmed/36033542
http://dx.doi.org/10.3389/fonc.2022.962702
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