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Outcomes of Wide Resection of Soft-Tissue Sarcoma of the Extremity: A Retrospective Analysis

Background Soft-tissue sarcomas (STSs) are a rare heterogeneous group of tumors. Good functional results can be achieved with tumor excision in combination with suitable supplemental adjuvant therapies if needed. This study aimed to investigate the outcomes of wide resection of STS of the extremitie...

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Autores principales: Sheoran, Ajay, Garg, Abhishek, Yadav, Umesh, Kundu, Zile Singh, Sherawat, Ravi, Singla, Mohit, Nemani, Mudit, Wason, Deepender, Kulaar, Harshdeep Singh, Singha, Sabuj Baran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413370/
https://www.ncbi.nlm.nih.gov/pubmed/36042997
http://dx.doi.org/10.7759/cureus.27329
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author Sheoran, Ajay
Garg, Abhishek
Yadav, Umesh
Kundu, Zile Singh
Sherawat, Ravi
Singla, Mohit
Nemani, Mudit
Wason, Deepender
Kulaar, Harshdeep Singh
Singha, Sabuj Baran
author_facet Sheoran, Ajay
Garg, Abhishek
Yadav, Umesh
Kundu, Zile Singh
Sherawat, Ravi
Singla, Mohit
Nemani, Mudit
Wason, Deepender
Kulaar, Harshdeep Singh
Singha, Sabuj Baran
author_sort Sheoran, Ajay
collection PubMed
description Background Soft-tissue sarcomas (STSs) are a rare heterogeneous group of tumors. Good functional results can be achieved with tumor excision in combination with suitable supplemental adjuvant therapies if needed. This study aimed to investigate the outcomes of wide resection of STS of the extremities. Methodology In this retrospective study, a total of 139 patients diagnosed with STS of the extremities by radiological and/or histopathological study/biopsy were included. All patients irrespective of metastasis were included. Results The mean age of the patients in our study was 43.5 ± 18.89 years. Overall, the mean tumor size was found to be 11.81 ± 6.218 cm. Malignant fibrous histiocytoma was the most common histology encountered (41%). Synovial sarcoma was the second most common histology encountered (14.38%). Recurrence was observed in 14 (10.1%) patients. The overall survival was 64.7% in our study. Conclusions The surgical margin achieved during the surgery is the most detrimental factor in local tumor control, and the overall survival of the patient after resection mainly depends on the stage of the tumor.
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spelling pubmed-94133702022-08-29 Outcomes of Wide Resection of Soft-Tissue Sarcoma of the Extremity: A Retrospective Analysis Sheoran, Ajay Garg, Abhishek Yadav, Umesh Kundu, Zile Singh Sherawat, Ravi Singla, Mohit Nemani, Mudit Wason, Deepender Kulaar, Harshdeep Singh Singha, Sabuj Baran Cureus Oncology Background Soft-tissue sarcomas (STSs) are a rare heterogeneous group of tumors. Good functional results can be achieved with tumor excision in combination with suitable supplemental adjuvant therapies if needed. This study aimed to investigate the outcomes of wide resection of STS of the extremities. Methodology In this retrospective study, a total of 139 patients diagnosed with STS of the extremities by radiological and/or histopathological study/biopsy were included. All patients irrespective of metastasis were included. Results The mean age of the patients in our study was 43.5 ± 18.89 years. Overall, the mean tumor size was found to be 11.81 ± 6.218 cm. Malignant fibrous histiocytoma was the most common histology encountered (41%). Synovial sarcoma was the second most common histology encountered (14.38%). Recurrence was observed in 14 (10.1%) patients. The overall survival was 64.7% in our study. Conclusions The surgical margin achieved during the surgery is the most detrimental factor in local tumor control, and the overall survival of the patient after resection mainly depends on the stage of the tumor. Cureus 2022-07-27 /pmc/articles/PMC9413370/ /pubmed/36042997 http://dx.doi.org/10.7759/cureus.27329 Text en Copyright © 2022, Sheoran et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Oncology
Sheoran, Ajay
Garg, Abhishek
Yadav, Umesh
Kundu, Zile Singh
Sherawat, Ravi
Singla, Mohit
Nemani, Mudit
Wason, Deepender
Kulaar, Harshdeep Singh
Singha, Sabuj Baran
Outcomes of Wide Resection of Soft-Tissue Sarcoma of the Extremity: A Retrospective Analysis
title Outcomes of Wide Resection of Soft-Tissue Sarcoma of the Extremity: A Retrospective Analysis
title_full Outcomes of Wide Resection of Soft-Tissue Sarcoma of the Extremity: A Retrospective Analysis
title_fullStr Outcomes of Wide Resection of Soft-Tissue Sarcoma of the Extremity: A Retrospective Analysis
title_full_unstemmed Outcomes of Wide Resection of Soft-Tissue Sarcoma of the Extremity: A Retrospective Analysis
title_short Outcomes of Wide Resection of Soft-Tissue Sarcoma of the Extremity: A Retrospective Analysis
title_sort outcomes of wide resection of soft-tissue sarcoma of the extremity: a retrospective analysis
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413370/
https://www.ncbi.nlm.nih.gov/pubmed/36042997
http://dx.doi.org/10.7759/cureus.27329
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