Cargando…

mRNA-Loaded Lipid Nanoparticles Targeting Dendritic Cells for Cancer Immunotherapy

Dendritic cells (DCs) are attractive antigen-presenting cells to be targeted for vaccinations. However, the systemic delivery of mRNA to DCs is hampered by technical challenges. We recently reported that it is possible to regulate the size of RNA-loaded lipid nanoparticles (LNPs) to over 200 nm with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sasaki, Kosuke, Sato, Yusuke, Okuda, Kento, Iwakawa, Kazuki, Harashima, Hideyoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413374/ https://www.ncbi.nlm.nih.gov/pubmed/36015198 http://dx.doi.org/10.3390/pharmaceutics14081572

Ejemplares similares

The silencing of indoleamine 2,3-dioxygenase 1 (IDO1) in dendritic cells by siRNA-loaded lipid nanoparticles enhances cell-based cancer immunotherapy
por: Endo, Rikito, et al.
Publicado: (2019)

mRNA-Loaded Lipid Nanoparticles Targeting Immune Cells in the Spleen for Use as Cancer Vaccines
por: Shimosakai, Ryoya, et al.
Publicado: (2022)

Mixing lipids to manipulate the ionization status of lipid nanoparticles for specific tissue targeting
por: Shobaki, Nour, et al.
Publicado: (2018)

Three-dimensional, symmetrically assembled microfluidic device for lipid nanoparticle production
por: Kimura, Niko, et al.
Publicado: (2021)

Genetically engineered transfusable platelets using mRNA lipid nanoparticles
por: Leung, Jerry, et al.
Publicado: (2023)

STING agonist loaded lipid nanoparticles overcome anti-PD-1 resistance in melanoma lung metastasis via NK cell activation
por: Nakamura, Takashi, et al.
Publicado: (2021)

Small-sized, stable lipid nanoparticle for the efficient delivery of siRNA to human immune cell lines
por: Nakamura, Takashi, et al.
Publicado: (2016)

Development of a Mitochondrial Targeting Lipid Nanoparticle Encapsulating Berberine
por: Hori, Ikuma, et al.
Publicado: (2023)

Advances in Lipid Nanoparticles for mRNA-Based Cancer Immunotherapy
por: Guevara, Maria L., et al.
Publicado: (2020)

Lipid Nanoparticles for mRNA Delivery to Enhance Cancer Immunotherapy
por: Wang, Hong-Li, et al.
Publicado: (2022)

Polysarcosine-Functionalized mRNA Lipid Nanoparticles Tailored for Immunotherapy
por: Wilhelmy, Christoph, et al.
Publicado: (2023)

Development of the iLiNP Device: Fine Tuning the Lipid Nanoparticle Size within 10 nm for Drug Delivery
por: Kimura, Niko, et al.
Publicado: (2018)

Lipid nanoparticle-based mRNA delivery systems for cancer immunotherapy
por: Han, Jieun, et al.
Publicado: (2023)

The delivery of mRNA to colon inflammatory lesions by lipid-nano-particles containing environmentally-sensitive lipid-like materials with oleic acid scaffolds
por: Tanaka, Hiroki, et al.
Publicado: (2018)

Understanding the formation mechanism of lipid nanoparticles in microfluidic devices with chaotic micromixers
por: Maeki, Masatoshi, et al.
Publicado: (2017)

Preparation and Characterization of IL-22 mRNA-loaded Lipid Nanoparticles
por: Alghoul, Zahra, et al.
Publicado: (2023)

Nanoparticles versus Dendritic Cells as Vehicles to Deliver mRNA Encoding Multiple Epitopes for Immunotherapy
por: Firdessa-Fite, Rebuma, et al.
Publicado: (2019)

Recent advancements in lipid–mRNA nanoparticles as a treatment option for cancer immunotherapy
por: Karmacharya, Prajeena, et al.
Publicado: (2022)

Novel PEGylated Lipid Nanoparticles Have a High Encapsulation Efficiency and Effectively Deliver MRTF-B siRNA in Conjunctival Fibroblasts
por: Sanghani, Amisha, et al.
Publicado: (2021)

Lipid nanoparticles for mRNA delivery
por: Hou, Xucheng, et al.
Publicado: (2021)

From lipids to lipid nanoparticles to mRNA vaccines
por: Horejs, Christine
Publicado: (2021)

mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy
por: Li, Fengqiao, et al.
Publicado: (2023)

Lipid–Polymer Hybrid Nanoparticles for mRNA Delivery to Dendritic Cells: Impact of Lipid Composition on Performance in Different Media
por: Kliesch, Lena, et al.
Publicado: (2022)

Kinetics of mRNA delivery and protein translation in dendritic cells using lipid-coated PLGA nanoparticles
por: Yasar, Hanzey, et al.
Publicado: (2018)

mRNA lipid nanoparticle phase transition
por: Trollmann, Marius F.W., et al.
Publicado: (2022)

Targeting Tumor Endothelial Cells with Nanoparticles
por: Sakurai, Yu, et al.
Publicado: (2019)

Application of apolipoprotein E-modified liposomal nanoparticles as a carrier for delivering DNA and nucleic acid in the brain
por: Tamaru, Mina, et al.
Publicado: (2014)

Optimization of ionizable lipids for aerosolizable mRNA lipid nanoparticles
por: Lewis, Mae M., et al.
Publicado: (2023)

Evolution of drug delivery system from viewpoint of controlled intracellular trafficking and selective tissue targeting toward future nanomedicine
por: Yamada, Yuma, et al.
Publicado: (2020)

In vitro optimization of 2′-OMe-4′-thioribonucleoside–modified anti-microRNA oligonucleotides and its targeting delivery to mouse liver using a liposomal nanoparticle
por: Takahashi, Mayumi, et al.
Publicado: (2013)

Lipid nanoparticles-loaded with toxin mRNA represents a new strategy for the treatment of solid tumors
por: Granot-Matok, Yasmin, et al.
Publicado: (2023)

Investigation of siRNA Nanoparticle Formation Using Mono-Cationic Detergents and Its Use in Gene Silencing in Human HeLa Cells
por: Yamada, Yuma, et al.
Publicado: (2013)

Optimization of a siRNA Carrier Modified with a pH-Sensitive Cationic Lipid and a Cyclic RGD Peptide for Efficiently Targeting Tumor Endothelial Cells
por: Hada, Tomoya, et al.
Publicado: (2015)

Immunotherapy of Tumor RNA-Loaded Lipid Nanoparticles Against Hepatocellular Carcinoma
por: Zhang, Yake, et al.
Publicado: (2021)

Delivery of mRNA to platelets using lipid nanoparticles
por: Novakowski, S., et al.
Publicado: (2019)

Ionizable lipid nanoparticles for in utero mRNA delivery
por: Riley, Rachel S., et al.
Publicado: (2021)

Payload distribution and capacity of mRNA lipid nanoparticles
por: Li, Sixuan, et al.
Publicado: (2022)

Recent Advances in Lipid Nanoparticles for Delivery of mRNA
por: Yang, Lei, et al.
Publicado: (2022)

Lipid-mRNA nanoparticles landscape for cancer therapy
por: Li, Yin, et al.
Publicado: (2022)

A KALA-modified lipid nanoparticle containing CpG-free plasmid DNA as a potential DNA vaccine carrier for antigen presentation and as an immune-stimulative adjuvant
por: Miura, Naoya, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_mf98ng4cdpum1pjpo720qie8q2