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Tailoring Diffusional Fields in Zwitterion/Dopamine Copolymer Electropolymerized at Carbon Nanowalls for Sensitive Recognition of Neurotransmitters

[Image: see text] The importance of neurotransmitter sensing in the diagnosis and treatment of many psychological illnesses and neurodegenerative diseases is non-negotiable. For electrochemical sensors to become widespread and accurate, a long journey must be undertaken for each device, from underst...

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Autores principales: Olejnik, Adrian, Ficek, Mateusz, Szkodo, Marek, Stanisławska, Alicja, Karczewski, Jakub, Ryl, Jacek, Dołęga, Anna, Siuzdak, Katarzyna, Bogdanowicz, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413423/
https://www.ncbi.nlm.nih.gov/pubmed/35868019
http://dx.doi.org/10.1021/acsnano.2c06406
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author Olejnik, Adrian
Ficek, Mateusz
Szkodo, Marek
Stanisławska, Alicja
Karczewski, Jakub
Ryl, Jacek
Dołęga, Anna
Siuzdak, Katarzyna
Bogdanowicz, Robert
author_facet Olejnik, Adrian
Ficek, Mateusz
Szkodo, Marek
Stanisławska, Alicja
Karczewski, Jakub
Ryl, Jacek
Dołęga, Anna
Siuzdak, Katarzyna
Bogdanowicz, Robert
author_sort Olejnik, Adrian
collection PubMed
description [Image: see text] The importance of neurotransmitter sensing in the diagnosis and treatment of many psychological illnesses and neurodegenerative diseases is non-negotiable. For electrochemical sensors to become widespread and accurate, a long journey must be undertaken for each device, from understanding the materials at the molecular level to real applications in biological fluids. We report a modification of diamondized boron-doped carbon nanowalls (BCNWs) with an electropolymerized polydopamine/polyzwitterion (PDA|PZ) coating revealing tunable mechanical and electrochemical properties. Zwitterions are codeposited with PDA and noncovalently incorporated into a structure. This approach causes a specific separation of the diffusion fields generated by each nanowall during electrochemical reactions, thus increasing the contribution of the steady-state currents in the amperometric response. This phenomenon has a profound effect on the sensing properties, leading to a 4-fold enhancement of the sensitivity (3.1 to 14.3 μA cm(–2) μM(–1)) and a 5-fold decrease of the limit of detection (505 to 89 nM) in comparison to the pristine BCNWs. Moreover, as a result of the antifouling capabilities of the incorporated zwitterions, this enhancement is preserved in bovine serum albumin (BSA) with a high protein concentration. The presence of zwitterion facilitates the transport of dopamine in the direction of the electrode by intermolecular interactions such as cation−π and hydrogen bonds. On the other hand, polydopamine units attached to the surface form molecular pockets driven by hydrogen bonds and π–π interactions. As a result, the intermediate state of dopamine–analyte oxidation is stabilized, leading to the enhancement of the sensing properties.
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spelling pubmed-94134232022-08-27 Tailoring Diffusional Fields in Zwitterion/Dopamine Copolymer Electropolymerized at Carbon Nanowalls for Sensitive Recognition of Neurotransmitters Olejnik, Adrian Ficek, Mateusz Szkodo, Marek Stanisławska, Alicja Karczewski, Jakub Ryl, Jacek Dołęga, Anna Siuzdak, Katarzyna Bogdanowicz, Robert ACS Nano [Image: see text] The importance of neurotransmitter sensing in the diagnosis and treatment of many psychological illnesses and neurodegenerative diseases is non-negotiable. For electrochemical sensors to become widespread and accurate, a long journey must be undertaken for each device, from understanding the materials at the molecular level to real applications in biological fluids. We report a modification of diamondized boron-doped carbon nanowalls (BCNWs) with an electropolymerized polydopamine/polyzwitterion (PDA|PZ) coating revealing tunable mechanical and electrochemical properties. Zwitterions are codeposited with PDA and noncovalently incorporated into a structure. This approach causes a specific separation of the diffusion fields generated by each nanowall during electrochemical reactions, thus increasing the contribution of the steady-state currents in the amperometric response. This phenomenon has a profound effect on the sensing properties, leading to a 4-fold enhancement of the sensitivity (3.1 to 14.3 μA cm(–2) μM(–1)) and a 5-fold decrease of the limit of detection (505 to 89 nM) in comparison to the pristine BCNWs. Moreover, as a result of the antifouling capabilities of the incorporated zwitterions, this enhancement is preserved in bovine serum albumin (BSA) with a high protein concentration. The presence of zwitterion facilitates the transport of dopamine in the direction of the electrode by intermolecular interactions such as cation−π and hydrogen bonds. On the other hand, polydopamine units attached to the surface form molecular pockets driven by hydrogen bonds and π–π interactions. As a result, the intermediate state of dopamine–analyte oxidation is stabilized, leading to the enhancement of the sensing properties. American Chemical Society 2022-07-22 2022-08-23 /pmc/articles/PMC9413423/ /pubmed/35868019 http://dx.doi.org/10.1021/acsnano.2c06406 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Olejnik, Adrian
Ficek, Mateusz
Szkodo, Marek
Stanisławska, Alicja
Karczewski, Jakub
Ryl, Jacek
Dołęga, Anna
Siuzdak, Katarzyna
Bogdanowicz, Robert
Tailoring Diffusional Fields in Zwitterion/Dopamine Copolymer Electropolymerized at Carbon Nanowalls for Sensitive Recognition of Neurotransmitters
title Tailoring Diffusional Fields in Zwitterion/Dopamine Copolymer Electropolymerized at Carbon Nanowalls for Sensitive Recognition of Neurotransmitters
title_full Tailoring Diffusional Fields in Zwitterion/Dopamine Copolymer Electropolymerized at Carbon Nanowalls for Sensitive Recognition of Neurotransmitters
title_fullStr Tailoring Diffusional Fields in Zwitterion/Dopamine Copolymer Electropolymerized at Carbon Nanowalls for Sensitive Recognition of Neurotransmitters
title_full_unstemmed Tailoring Diffusional Fields in Zwitterion/Dopamine Copolymer Electropolymerized at Carbon Nanowalls for Sensitive Recognition of Neurotransmitters
title_short Tailoring Diffusional Fields in Zwitterion/Dopamine Copolymer Electropolymerized at Carbon Nanowalls for Sensitive Recognition of Neurotransmitters
title_sort tailoring diffusional fields in zwitterion/dopamine copolymer electropolymerized at carbon nanowalls for sensitive recognition of neurotransmitters
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413423/
https://www.ncbi.nlm.nih.gov/pubmed/35868019
http://dx.doi.org/10.1021/acsnano.2c06406
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