An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections

[Image: see text] Genomic studies and experiments with permeability-deficient strains have revealed a variety of biological targets that can be engaged to kill Gram-negative bacteria. However, the formidable outer membrane and promiscuous efflux pumps of these pathogens prevent many candidate antibi...

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Detalles Bibliográficos
Autores principales: Parker, Erica N., Cain, Brett N., Hajian, Behnoush, Ulrich, Rebecca J., Geddes, Emily J., Barkho, Sulyman, Lee, Hyang Yeon, Williams, John D., Raynor, Malik, Caridha, Diana, Zaino, Angela, Shekhar, Mrinal, Muñoz, Kristen A., Rzasa, Kara M., Temple, Emily R., Hunt, Diana, Jin, Xiannu, Vuong, Chau, Pannone, Kristina, Kelly, Aya M., Mulligan, Michael P., Lee, Katie K., Lau, Gee W., Hung, Deborah T., Hergenrother, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413440/
https://www.ncbi.nlm.nih.gov/pubmed/36032774
http://dx.doi.org/10.1021/acscentsci.2c00598

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