Small but strong: Pivotal roles and potential applications of snoRNAs in hematopoietic malignancies

Small nucleolar RNAs (snoRNAs) belong to a family of noncoding RNAs that are 60-300 nucleotides in length, and they are classified into two classes according to their structure and function: C/D box snoRNAs, playing an essential role in 2’-O-methylation modification on ribosomal RNA; H/ACA box snoRN...

Descripción completa

Detalles Bibliográficos
Autores principales: Dong, Jian, Wang, Hui, Zhang, Zhaoru, Yang, Lin, Qian, Xinyue, Qian, Wenchang, Han, Yingli, Huang, He, Qian, Pengxu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413531/
https://www.ncbi.nlm.nih.gov/pubmed/36033520
http://dx.doi.org/10.3389/fonc.2022.939465
_version_ 1784775772160917504
author Dong, Jian
Wang, Hui
Zhang, Zhaoru
Yang, Lin
Qian, Xinyue
Qian, Wenchang
Han, Yingli
Huang, He
Qian, Pengxu
author_facet Dong, Jian
Wang, Hui
Zhang, Zhaoru
Yang, Lin
Qian, Xinyue
Qian, Wenchang
Han, Yingli
Huang, He
Qian, Pengxu
author_sort Dong, Jian
collection PubMed
description Small nucleolar RNAs (snoRNAs) belong to a family of noncoding RNAs that are 60-300 nucleotides in length, and they are classified into two classes according to their structure and function: C/D box snoRNAs, playing an essential role in 2’-O-methylation modification on ribosomal RNA; H/ACA box snoRNAs, involved in the pseudouridylation of rRNA. SnoRNAs with unclear functions, no predictable targets, and unusual subcellular locations are called orphan snoRNAs. Recent studies have revealed abnormal expression and demonstrated the pivotal roles of snoRNAs and their host genes in various types of hematological malignancies. This review discusses recent discoveries concerning snoRNAs in a variety of hematological malignancies, including multiple myeloma, lymphoma and leukemia, and sheds light on the application of snoRNAs as diagnostic and prognostic markers as well as therapeutic targets of hematological malignancies in the future.
format Online
Article
Text
id pubmed-9413531
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-94135312022-08-27 Small but strong: Pivotal roles and potential applications of snoRNAs in hematopoietic malignancies Dong, Jian Wang, Hui Zhang, Zhaoru Yang, Lin Qian, Xinyue Qian, Wenchang Han, Yingli Huang, He Qian, Pengxu Front Oncol Oncology Small nucleolar RNAs (snoRNAs) belong to a family of noncoding RNAs that are 60-300 nucleotides in length, and they are classified into two classes according to their structure and function: C/D box snoRNAs, playing an essential role in 2’-O-methylation modification on ribosomal RNA; H/ACA box snoRNAs, involved in the pseudouridylation of rRNA. SnoRNAs with unclear functions, no predictable targets, and unusual subcellular locations are called orphan snoRNAs. Recent studies have revealed abnormal expression and demonstrated the pivotal roles of snoRNAs and their host genes in various types of hematological malignancies. This review discusses recent discoveries concerning snoRNAs in a variety of hematological malignancies, including multiple myeloma, lymphoma and leukemia, and sheds light on the application of snoRNAs as diagnostic and prognostic markers as well as therapeutic targets of hematological malignancies in the future. Frontiers Media S.A. 2022-08-12 /pmc/articles/PMC9413531/ /pubmed/36033520 http://dx.doi.org/10.3389/fonc.2022.939465 Text en Copyright © 2022 Dong, Wang, Zhang, Yang, Qian, Qian, Han, Huang and Qian https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Dong, Jian
Wang, Hui
Zhang, Zhaoru
Yang, Lin
Qian, Xinyue
Qian, Wenchang
Han, Yingli
Huang, He
Qian, Pengxu
Small but strong: Pivotal roles and potential applications of snoRNAs in hematopoietic malignancies
title Small but strong: Pivotal roles and potential applications of snoRNAs in hematopoietic malignancies
title_full Small but strong: Pivotal roles and potential applications of snoRNAs in hematopoietic malignancies
title_fullStr Small but strong: Pivotal roles and potential applications of snoRNAs in hematopoietic malignancies
title_full_unstemmed Small but strong: Pivotal roles and potential applications of snoRNAs in hematopoietic malignancies
title_short Small but strong: Pivotal roles and potential applications of snoRNAs in hematopoietic malignancies
title_sort small but strong: pivotal roles and potential applications of snornas in hematopoietic malignancies
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413531/
https://www.ncbi.nlm.nih.gov/pubmed/36033520
http://dx.doi.org/10.3389/fonc.2022.939465
work_keys_str_mv AT dongjian smallbutstrongpivotalrolesandpotentialapplicationsofsnornasinhematopoieticmalignancies
AT wanghui smallbutstrongpivotalrolesandpotentialapplicationsofsnornasinhematopoieticmalignancies
AT zhangzhaoru smallbutstrongpivotalrolesandpotentialapplicationsofsnornasinhematopoieticmalignancies
AT yanglin smallbutstrongpivotalrolesandpotentialapplicationsofsnornasinhematopoieticmalignancies
AT qianxinyue smallbutstrongpivotalrolesandpotentialapplicationsofsnornasinhematopoieticmalignancies
AT qianwenchang smallbutstrongpivotalrolesandpotentialapplicationsofsnornasinhematopoieticmalignancies
AT hanyingli smallbutstrongpivotalrolesandpotentialapplicationsofsnornasinhematopoieticmalignancies
AT huanghe smallbutstrongpivotalrolesandpotentialapplicationsofsnornasinhematopoieticmalignancies
AT qianpengxu smallbutstrongpivotalrolesandpotentialapplicationsofsnornasinhematopoieticmalignancies

Ejemplares similares