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Quercetin-3-O-β-D-Glucopyranoside-Rich Fraction from Spondias mombin Leaves Halted Responses from Oxidative Stress, Neuroinflammation, Apoptosis, and Lipid Peroxidation in the Brain of Dichlorvos-Treated Wistar Rats

HIGHLIGHTS: Protective efficacy of Quercetin-3-O-β-D-glucopyranoside-rich fraction (Q3G-RF) from Spondias mombin role on Dichlorvos (DDVP) toxicity was studied. DDVP induced cognitive and locomotive impairment, free radicals, oxidative stress, neuroinflammation, and apoptosis in the brain of rats. Q...

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Autores principales: Ogunro, Olalekan Bukunmi, Salawu, Akeem Oni, Alotaibi, Saqer S., Albogami, Sarah M., Batiha, Gaber El-Saber, Waard, Michel De
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413772/
https://www.ncbi.nlm.nih.gov/pubmed/36006156
http://dx.doi.org/10.3390/toxics10080477
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author Ogunro, Olalekan Bukunmi
Salawu, Akeem Oni
Alotaibi, Saqer S.
Albogami, Sarah M.
Batiha, Gaber El-Saber
Waard, Michel De
author_facet Ogunro, Olalekan Bukunmi
Salawu, Akeem Oni
Alotaibi, Saqer S.
Albogami, Sarah M.
Batiha, Gaber El-Saber
Waard, Michel De
author_sort Ogunro, Olalekan Bukunmi
collection PubMed
description HIGHLIGHTS: Protective efficacy of Quercetin-3-O-β-D-glucopyranoside-rich fraction (Q3G-RF) from Spondias mombin role on Dichlorvos (DDVP) toxicity was studied. DDVP induced cognitive and locomotive impairment, free radicals, oxidative stress, neuroinflammation, and apoptosis in the brain of rats. Q3G-RF from S. mombin leaves prevented DDVP-induced cognitive and locomotion impairment in the rats. Q3G-RF from S. mombin leaves prevented DDVP-induced deficits in fluid intake and body weight of the rats. Q3G-RF from S. mombin leaves abated DDVP-induced inhibition of AChE, BuChE in the brain sections of rats. Q3G-RF from S. mombin leaves reversed elevated activities APEH, DPP-IV and POP in the brain sections of rats exposed to DDVP. Q3G-RF from S. mombin leaves revoked the DDVP-induced oxidative stress in the brain sections of rats. Q3G-RF from S. mombin leaves prevented DDVP-induced neuroinflammation in the brain sections of rats. Q3G-RF from S. mombin leaves reversed DDVP-induced apoptosis in the brain sections of rats. Q3G-RF from S. mombin leaves assuaged DDVP neural toxicity in the brain sections of rats via anti-oxidative and anti-inflammatory mechanisms. ABSTARCT: The study investigated the prophylactic efficacy of Quercetin-3-O-β-D-glucopyranoside-rich fraction (Q3G-RF) from Spondias mombin leaves on oxidative and neuronal damages in the brain sections of dichlorvos (DDVP)-treated female Wistar rats. Female Wistar rats assigned into 5 groups of 12 rats each were orally treated with appropriate regimens. Group 1 received sunflower oil. Group 2 received DDVP (8.8 mg/kg). Group 3 received Q3G-RF (100 mg/kg). Group 4 received DDVP + Q3G-RF (50 mg/kg). Group 5 received DDVP + Q3G-RF (100 mg/kg). Q3G-RF reversed DDVP-induced cognitive deficits in the rats and reversed rearing activity impairment; it protected against the following DDVP-induced activities: inhibition of cholinesterases (acetylcholinestere (AChE), butyrylcholinesterase (BuChE)), elevated marker-enzymes (acylpeptide hydrolase (APEH), dipeptidylpeptidase IV (DPP-IV), prolyl oligopeptidase (POP)), oxidative stress (total thiol, malondialdehyde, hydrogen peroxide (H(2)O(2)), reduced glutathione and the activities glutathione S-transferase, catalase, superoxide dismutase, and glutathione peroxidase), inflammation (myeloperoxidase (MPO), tumor necrosis factor-α (TNF-α), nitric oxide, interleukin-1 beta (IL-1β)), and apoptosis (caspase-3) in the hippocampus, striatum, and prefrontal cortex of the experimental rats exposed to DDVP (p < 0.05). Conclusively, the neuroprotective effects of Q3G-RF on DDVP-induced toxicity in the hippocampus, striatum, and prefrontal cortex in brain of rats suggests its potent antioxidant, prophylactic, and chemotherapeutic properties.
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spelling pubmed-94137722022-08-27 Quercetin-3-O-β-D-Glucopyranoside-Rich Fraction from Spondias mombin Leaves Halted Responses from Oxidative Stress, Neuroinflammation, Apoptosis, and Lipid Peroxidation in the Brain of Dichlorvos-Treated Wistar Rats Ogunro, Olalekan Bukunmi Salawu, Akeem Oni Alotaibi, Saqer S. Albogami, Sarah M. Batiha, Gaber El-Saber Waard, Michel De Toxics Article HIGHLIGHTS: Protective efficacy of Quercetin-3-O-β-D-glucopyranoside-rich fraction (Q3G-RF) from Spondias mombin role on Dichlorvos (DDVP) toxicity was studied. DDVP induced cognitive and locomotive impairment, free radicals, oxidative stress, neuroinflammation, and apoptosis in the brain of rats. Q3G-RF from S. mombin leaves prevented DDVP-induced cognitive and locomotion impairment in the rats. Q3G-RF from S. mombin leaves prevented DDVP-induced deficits in fluid intake and body weight of the rats. Q3G-RF from S. mombin leaves abated DDVP-induced inhibition of AChE, BuChE in the brain sections of rats. Q3G-RF from S. mombin leaves reversed elevated activities APEH, DPP-IV and POP in the brain sections of rats exposed to DDVP. Q3G-RF from S. mombin leaves revoked the DDVP-induced oxidative stress in the brain sections of rats. Q3G-RF from S. mombin leaves prevented DDVP-induced neuroinflammation in the brain sections of rats. Q3G-RF from S. mombin leaves reversed DDVP-induced apoptosis in the brain sections of rats. Q3G-RF from S. mombin leaves assuaged DDVP neural toxicity in the brain sections of rats via anti-oxidative and anti-inflammatory mechanisms. ABSTARCT: The study investigated the prophylactic efficacy of Quercetin-3-O-β-D-glucopyranoside-rich fraction (Q3G-RF) from Spondias mombin leaves on oxidative and neuronal damages in the brain sections of dichlorvos (DDVP)-treated female Wistar rats. Female Wistar rats assigned into 5 groups of 12 rats each were orally treated with appropriate regimens. Group 1 received sunflower oil. Group 2 received DDVP (8.8 mg/kg). Group 3 received Q3G-RF (100 mg/kg). Group 4 received DDVP + Q3G-RF (50 mg/kg). Group 5 received DDVP + Q3G-RF (100 mg/kg). Q3G-RF reversed DDVP-induced cognitive deficits in the rats and reversed rearing activity impairment; it protected against the following DDVP-induced activities: inhibition of cholinesterases (acetylcholinestere (AChE), butyrylcholinesterase (BuChE)), elevated marker-enzymes (acylpeptide hydrolase (APEH), dipeptidylpeptidase IV (DPP-IV), prolyl oligopeptidase (POP)), oxidative stress (total thiol, malondialdehyde, hydrogen peroxide (H(2)O(2)), reduced glutathione and the activities glutathione S-transferase, catalase, superoxide dismutase, and glutathione peroxidase), inflammation (myeloperoxidase (MPO), tumor necrosis factor-α (TNF-α), nitric oxide, interleukin-1 beta (IL-1β)), and apoptosis (caspase-3) in the hippocampus, striatum, and prefrontal cortex of the experimental rats exposed to DDVP (p < 0.05). Conclusively, the neuroprotective effects of Q3G-RF on DDVP-induced toxicity in the hippocampus, striatum, and prefrontal cortex in brain of rats suggests its potent antioxidant, prophylactic, and chemotherapeutic properties. MDPI 2022-08-16 /pmc/articles/PMC9413772/ /pubmed/36006156 http://dx.doi.org/10.3390/toxics10080477 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ogunro, Olalekan Bukunmi
Salawu, Akeem Oni
Alotaibi, Saqer S.
Albogami, Sarah M.
Batiha, Gaber El-Saber
Waard, Michel De
Quercetin-3-O-β-D-Glucopyranoside-Rich Fraction from Spondias mombin Leaves Halted Responses from Oxidative Stress, Neuroinflammation, Apoptosis, and Lipid Peroxidation in the Brain of Dichlorvos-Treated Wistar Rats
title Quercetin-3-O-β-D-Glucopyranoside-Rich Fraction from Spondias mombin Leaves Halted Responses from Oxidative Stress, Neuroinflammation, Apoptosis, and Lipid Peroxidation in the Brain of Dichlorvos-Treated Wistar Rats
title_full Quercetin-3-O-β-D-Glucopyranoside-Rich Fraction from Spondias mombin Leaves Halted Responses from Oxidative Stress, Neuroinflammation, Apoptosis, and Lipid Peroxidation in the Brain of Dichlorvos-Treated Wistar Rats
title_fullStr Quercetin-3-O-β-D-Glucopyranoside-Rich Fraction from Spondias mombin Leaves Halted Responses from Oxidative Stress, Neuroinflammation, Apoptosis, and Lipid Peroxidation in the Brain of Dichlorvos-Treated Wistar Rats
title_full_unstemmed Quercetin-3-O-β-D-Glucopyranoside-Rich Fraction from Spondias mombin Leaves Halted Responses from Oxidative Stress, Neuroinflammation, Apoptosis, and Lipid Peroxidation in the Brain of Dichlorvos-Treated Wistar Rats
title_short Quercetin-3-O-β-D-Glucopyranoside-Rich Fraction from Spondias mombin Leaves Halted Responses from Oxidative Stress, Neuroinflammation, Apoptosis, and Lipid Peroxidation in the Brain of Dichlorvos-Treated Wistar Rats
title_sort quercetin-3-o-β-d-glucopyranoside-rich fraction from spondias mombin leaves halted responses from oxidative stress, neuroinflammation, apoptosis, and lipid peroxidation in the brain of dichlorvos-treated wistar rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413772/
https://www.ncbi.nlm.nih.gov/pubmed/36006156
http://dx.doi.org/10.3390/toxics10080477
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