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Japanese Spotted Fever and Irreversible Renal Dysfunction during Immunosuppressive Therapy after a Living-Donor Kidney Transplant

Ten years ago, a 56-year-old woman with a history of IgA nephropathy who received a living-donor kidney transplant across ABO barriers was managed with immunosuppressive drugs. The kidney transplant donor was her father who had poor kidney function. The patient’s renal function was stable for 10 yea...

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Autores principales: Kondo, Makoto, Nishikawa, Kohei, Iida, Shohei, Nakanishi, Takehisa, Habe, Koji, Yamanaka, Keiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413776/
https://www.ncbi.nlm.nih.gov/pubmed/36006267
http://dx.doi.org/10.3390/tropicalmed7080175
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author Kondo, Makoto
Nishikawa, Kohei
Iida, Shohei
Nakanishi, Takehisa
Habe, Koji
Yamanaka, Keiichi
author_facet Kondo, Makoto
Nishikawa, Kohei
Iida, Shohei
Nakanishi, Takehisa
Habe, Koji
Yamanaka, Keiichi
author_sort Kondo, Makoto
collection PubMed
description Ten years ago, a 56-year-old woman with a history of IgA nephropathy who received a living-donor kidney transplant across ABO barriers was managed with immunosuppressive drugs. The kidney transplant donor was her father who had poor kidney function. The patient’s renal function was stable for 10 years. The patient visited our department with a complaint of skin rash, occurring 2 days after an onset of fever. Although a skin rash is atypical for Japanese spotted fever (JSF), we suspected JSF and started treatment with minocycline because we found a scar suggestive of an eschar. Furthermore, the blood test results were similar to those associated with JSF, and the patient lived in a JSF-endemic area. The patient’s symptoms improved after 1 week. She was diagnosed with JSF by serological tests against Rickettsia japonica. JSF usually does not cause any complications after recovery. However, the patient’s renal function did not completely recover. JSF can cause an atypical rash in patients taking excessive immunosuppressive drugs. Early treatment is required for patients with suspected JSF to prevent complications of renal dysfunction after receiving a living-donor kidney transplant.
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spelling pubmed-94137762022-08-27 Japanese Spotted Fever and Irreversible Renal Dysfunction during Immunosuppressive Therapy after a Living-Donor Kidney Transplant Kondo, Makoto Nishikawa, Kohei Iida, Shohei Nakanishi, Takehisa Habe, Koji Yamanaka, Keiichi Trop Med Infect Dis Case Report Ten years ago, a 56-year-old woman with a history of IgA nephropathy who received a living-donor kidney transplant across ABO barriers was managed with immunosuppressive drugs. The kidney transplant donor was her father who had poor kidney function. The patient’s renal function was stable for 10 years. The patient visited our department with a complaint of skin rash, occurring 2 days after an onset of fever. Although a skin rash is atypical for Japanese spotted fever (JSF), we suspected JSF and started treatment with minocycline because we found a scar suggestive of an eschar. Furthermore, the blood test results were similar to those associated with JSF, and the patient lived in a JSF-endemic area. The patient’s symptoms improved after 1 week. She was diagnosed with JSF by serological tests against Rickettsia japonica. JSF usually does not cause any complications after recovery. However, the patient’s renal function did not completely recover. JSF can cause an atypical rash in patients taking excessive immunosuppressive drugs. Early treatment is required for patients with suspected JSF to prevent complications of renal dysfunction after receiving a living-donor kidney transplant. MDPI 2022-08-10 /pmc/articles/PMC9413776/ /pubmed/36006267 http://dx.doi.org/10.3390/tropicalmed7080175 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Kondo, Makoto
Nishikawa, Kohei
Iida, Shohei
Nakanishi, Takehisa
Habe, Koji
Yamanaka, Keiichi
Japanese Spotted Fever and Irreversible Renal Dysfunction during Immunosuppressive Therapy after a Living-Donor Kidney Transplant
title Japanese Spotted Fever and Irreversible Renal Dysfunction during Immunosuppressive Therapy after a Living-Donor Kidney Transplant
title_full Japanese Spotted Fever and Irreversible Renal Dysfunction during Immunosuppressive Therapy after a Living-Donor Kidney Transplant
title_fullStr Japanese Spotted Fever and Irreversible Renal Dysfunction during Immunosuppressive Therapy after a Living-Donor Kidney Transplant
title_full_unstemmed Japanese Spotted Fever and Irreversible Renal Dysfunction during Immunosuppressive Therapy after a Living-Donor Kidney Transplant
title_short Japanese Spotted Fever and Irreversible Renal Dysfunction during Immunosuppressive Therapy after a Living-Donor Kidney Transplant
title_sort japanese spotted fever and irreversible renal dysfunction during immunosuppressive therapy after a living-donor kidney transplant
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413776/
https://www.ncbi.nlm.nih.gov/pubmed/36006267
http://dx.doi.org/10.3390/tropicalmed7080175
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