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Real-World Effectiveness of a Booster Dose of the COVID-19 Vaccines among Japanese University Students
With the spread of the Coronavirus disease 2019 (COVID-19), missing learning opportunities due to COVID-19 has been raised as a major concern for university education. We aimed to examine the effectiveness of a booster dose of COVID-19 vaccines among Japanese university students during the spread of...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413816/ https://www.ncbi.nlm.nih.gov/pubmed/36016171 http://dx.doi.org/10.3390/vaccines10081283 |
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author | Miyauchi, Shunsuke Hiyama, Toru Nakano, Yukiko Yoshida, Mahoko Yoshino, Atsuo Miyake, Yoshie Okamoto, Yuri |
author_facet | Miyauchi, Shunsuke Hiyama, Toru Nakano, Yukiko Yoshida, Mahoko Yoshino, Atsuo Miyake, Yoshie Okamoto, Yuri |
author_sort | Miyauchi, Shunsuke |
collection | PubMed |
description | With the spread of the Coronavirus disease 2019 (COVID-19), missing learning opportunities due to COVID-19 has been raised as a major concern for university education. We aimed to examine the effectiveness of a booster dose of COVID-19 vaccines among Japanese university students during the spread of the Omicron variant. We enrolled 249 students who became a close contact and 294 COVID-19-infected students though the Hiroshima University COVID-19 registration system. Infection rates of people in close contact with sick individuals and symptoms of infected students were examined. Close contacts who had received a booster dose showed a significantly lower infection rate (31%) compared with those with two doses (50%, p = 0.02) and the unvaccinated (71%, p = 0.002). Age- and sex-adjusted odds ratios of receipt of a booster dose vs. two doses and unvaccinated were 0.40 (95% confidence interval [CI], 0.23–0.70, p = 0.001) and 0.44 (95% CI, 0.25–0.77, p = 0.004), respectively. The incidence of severe fever (38.5°C or higher) was significantly less prevalent in those with a booster dose (16%) compared with two doses (40%, p = 0.002) and those who were unvaccinated (75%, p < 0.0001). Booster doses reduced infection rates among close-contact students and can help students to avoid missing learning opportunities. |
format | Online Article Text |
id | pubmed-9413816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94138162022-08-27 Real-World Effectiveness of a Booster Dose of the COVID-19 Vaccines among Japanese University Students Miyauchi, Shunsuke Hiyama, Toru Nakano, Yukiko Yoshida, Mahoko Yoshino, Atsuo Miyake, Yoshie Okamoto, Yuri Vaccines (Basel) Article With the spread of the Coronavirus disease 2019 (COVID-19), missing learning opportunities due to COVID-19 has been raised as a major concern for university education. We aimed to examine the effectiveness of a booster dose of COVID-19 vaccines among Japanese university students during the spread of the Omicron variant. We enrolled 249 students who became a close contact and 294 COVID-19-infected students though the Hiroshima University COVID-19 registration system. Infection rates of people in close contact with sick individuals and symptoms of infected students were examined. Close contacts who had received a booster dose showed a significantly lower infection rate (31%) compared with those with two doses (50%, p = 0.02) and the unvaccinated (71%, p = 0.002). Age- and sex-adjusted odds ratios of receipt of a booster dose vs. two doses and unvaccinated were 0.40 (95% confidence interval [CI], 0.23–0.70, p = 0.001) and 0.44 (95% CI, 0.25–0.77, p = 0.004), respectively. The incidence of severe fever (38.5°C or higher) was significantly less prevalent in those with a booster dose (16%) compared with two doses (40%, p = 0.002) and those who were unvaccinated (75%, p < 0.0001). Booster doses reduced infection rates among close-contact students and can help students to avoid missing learning opportunities. MDPI 2022-08-09 /pmc/articles/PMC9413816/ /pubmed/36016171 http://dx.doi.org/10.3390/vaccines10081283 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Miyauchi, Shunsuke Hiyama, Toru Nakano, Yukiko Yoshida, Mahoko Yoshino, Atsuo Miyake, Yoshie Okamoto, Yuri Real-World Effectiveness of a Booster Dose of the COVID-19 Vaccines among Japanese University Students |
title | Real-World Effectiveness of a Booster Dose of the COVID-19 Vaccines among Japanese University Students |
title_full | Real-World Effectiveness of a Booster Dose of the COVID-19 Vaccines among Japanese University Students |
title_fullStr | Real-World Effectiveness of a Booster Dose of the COVID-19 Vaccines among Japanese University Students |
title_full_unstemmed | Real-World Effectiveness of a Booster Dose of the COVID-19 Vaccines among Japanese University Students |
title_short | Real-World Effectiveness of a Booster Dose of the COVID-19 Vaccines among Japanese University Students |
title_sort | real-world effectiveness of a booster dose of the covid-19 vaccines among japanese university students |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413816/ https://www.ncbi.nlm.nih.gov/pubmed/36016171 http://dx.doi.org/10.3390/vaccines10081283 |
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