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Real-World Effectiveness of a Booster Dose of the COVID-19 Vaccines among Japanese University Students

With the spread of the Coronavirus disease 2019 (COVID-19), missing learning opportunities due to COVID-19 has been raised as a major concern for university education. We aimed to examine the effectiveness of a booster dose of COVID-19 vaccines among Japanese university students during the spread of...

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Autores principales: Miyauchi, Shunsuke, Hiyama, Toru, Nakano, Yukiko, Yoshida, Mahoko, Yoshino, Atsuo, Miyake, Yoshie, Okamoto, Yuri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413816/
https://www.ncbi.nlm.nih.gov/pubmed/36016171
http://dx.doi.org/10.3390/vaccines10081283
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author Miyauchi, Shunsuke
Hiyama, Toru
Nakano, Yukiko
Yoshida, Mahoko
Yoshino, Atsuo
Miyake, Yoshie
Okamoto, Yuri
author_facet Miyauchi, Shunsuke
Hiyama, Toru
Nakano, Yukiko
Yoshida, Mahoko
Yoshino, Atsuo
Miyake, Yoshie
Okamoto, Yuri
author_sort Miyauchi, Shunsuke
collection PubMed
description With the spread of the Coronavirus disease 2019 (COVID-19), missing learning opportunities due to COVID-19 has been raised as a major concern for university education. We aimed to examine the effectiveness of a booster dose of COVID-19 vaccines among Japanese university students during the spread of the Omicron variant. We enrolled 249 students who became a close contact and 294 COVID-19-infected students though the Hiroshima University COVID-19 registration system. Infection rates of people in close contact with sick individuals and symptoms of infected students were examined. Close contacts who had received a booster dose showed a significantly lower infection rate (31%) compared with those with two doses (50%, p = 0.02) and the unvaccinated (71%, p = 0.002). Age- and sex-adjusted odds ratios of receipt of a booster dose vs. two doses and unvaccinated were 0.40 (95% confidence interval [CI], 0.23–0.70, p = 0.001) and 0.44 (95% CI, 0.25–0.77, p = 0.004), respectively. The incidence of severe fever (38.5°C or higher) was significantly less prevalent in those with a booster dose (16%) compared with two doses (40%, p = 0.002) and those who were unvaccinated (75%, p < 0.0001). Booster doses reduced infection rates among close-contact students and can help students to avoid missing learning opportunities.
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spelling pubmed-94138162022-08-27 Real-World Effectiveness of a Booster Dose of the COVID-19 Vaccines among Japanese University Students Miyauchi, Shunsuke Hiyama, Toru Nakano, Yukiko Yoshida, Mahoko Yoshino, Atsuo Miyake, Yoshie Okamoto, Yuri Vaccines (Basel) Article With the spread of the Coronavirus disease 2019 (COVID-19), missing learning opportunities due to COVID-19 has been raised as a major concern for university education. We aimed to examine the effectiveness of a booster dose of COVID-19 vaccines among Japanese university students during the spread of the Omicron variant. We enrolled 249 students who became a close contact and 294 COVID-19-infected students though the Hiroshima University COVID-19 registration system. Infection rates of people in close contact with sick individuals and symptoms of infected students were examined. Close contacts who had received a booster dose showed a significantly lower infection rate (31%) compared with those with two doses (50%, p = 0.02) and the unvaccinated (71%, p = 0.002). Age- and sex-adjusted odds ratios of receipt of a booster dose vs. two doses and unvaccinated were 0.40 (95% confidence interval [CI], 0.23–0.70, p = 0.001) and 0.44 (95% CI, 0.25–0.77, p = 0.004), respectively. The incidence of severe fever (38.5°C or higher) was significantly less prevalent in those with a booster dose (16%) compared with two doses (40%, p = 0.002) and those who were unvaccinated (75%, p < 0.0001). Booster doses reduced infection rates among close-contact students and can help students to avoid missing learning opportunities. MDPI 2022-08-09 /pmc/articles/PMC9413816/ /pubmed/36016171 http://dx.doi.org/10.3390/vaccines10081283 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Miyauchi, Shunsuke
Hiyama, Toru
Nakano, Yukiko
Yoshida, Mahoko
Yoshino, Atsuo
Miyake, Yoshie
Okamoto, Yuri
Real-World Effectiveness of a Booster Dose of the COVID-19 Vaccines among Japanese University Students
title Real-World Effectiveness of a Booster Dose of the COVID-19 Vaccines among Japanese University Students
title_full Real-World Effectiveness of a Booster Dose of the COVID-19 Vaccines among Japanese University Students
title_fullStr Real-World Effectiveness of a Booster Dose of the COVID-19 Vaccines among Japanese University Students
title_full_unstemmed Real-World Effectiveness of a Booster Dose of the COVID-19 Vaccines among Japanese University Students
title_short Real-World Effectiveness of a Booster Dose of the COVID-19 Vaccines among Japanese University Students
title_sort real-world effectiveness of a booster dose of the covid-19 vaccines among japanese university students
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413816/
https://www.ncbi.nlm.nih.gov/pubmed/36016171
http://dx.doi.org/10.3390/vaccines10081283
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