Human T-bet governs the generation of a distinct subset of CD11c(high)CD21(low) B cells

High level expression of the transcription factor T-bet characterizes a phenotypically distinct murine B-cell population known as ‘age-associated B cells’ (ABCs). T-bet-deficient mice have reduced ABCs and impaired humoral immunity. We describe a patient with inherited T-bet deficiency and largely n...

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Detalles Bibliográficos
Autores principales: Yang, Rui, Avery, Danielle T., Jackson, Katherine J. L., Ogishi, Masato, Benhsaien, Ibtihal, Du, Likun, Ye, Xiaofei, Han, Jing, Rosain, Jérémie, Peel, Jessica N., Alyanakian, Marie-Alexandra, Neven, Bénédicte, Winter, Sarah, Puel, Anne, Boisson, Bertrand, Payne, Kathryn J., Wong, Melanie, Russell, Amanda J., Mizoguchi, Yoko, Okada, Satoshi, Uzel, Gulbu, Goodnow, Christopher C., Latour, Sylvain, Bakkouri, Jalila El, Bousfiha, Aziz, Preece, Kahn, Gray, Paul E., Keller, Baerbel, Warnatz, Klaus, Boisson-Dupuis, Stéphanie, Abel, Laurent, Pan-Hammarström, Qiang, Bustamante, Jacinta, Ma, Cindy S., Casanova, Jean-Laurent, Tangye, Stuart G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413977/
https://www.ncbi.nlm.nih.gov/pubmed/35867801
http://dx.doi.org/10.1126/sciimmunol.abq3277

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